In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins
Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulat...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/879676 |
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| author | Yun-Jie Dang Han-Zhou Feng Limei Zhang Chun-Hui Hu Chun-Yan Zhu |
| author_facet | Yun-Jie Dang Han-Zhou Feng Limei Zhang Chun-Hui Hu Chun-Yan Zhu |
| author_sort | Yun-Jie Dang |
| collection | DOAJ |
| description | Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method. We studied the absorption property of ACGs in rat’s intestine, which showed there was a good absorption and uptake percentages with solid dispersion. The study on uptake percentage in different regions of rat’s intestine attested that the duodenum had the best permeability, followed by jejunum, ileum, and colon in order with no significant differences. So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins. |
| format | Article |
| id | doaj-art-d06d4ecb43474edd98160443c656d186 |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d06d4ecb43474edd98160443c656d1862025-08-20T03:19:43ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/879676879676In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous AcetogeninsYun-Jie Dang0Han-Zhou Feng1Limei Zhang2Chun-Hui Hu3Chun-Yan Zhu4Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, ChinaIsolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method. We studied the absorption property of ACGs in rat’s intestine, which showed there was a good absorption and uptake percentages with solid dispersion. The study on uptake percentage in different regions of rat’s intestine attested that the duodenum had the best permeability, followed by jejunum, ileum, and colon in order with no significant differences. So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins.http://dx.doi.org/10.1155/2012/879676 |
| spellingShingle | Yun-Jie Dang Han-Zhou Feng Limei Zhang Chun-Hui Hu Chun-Yan Zhu In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins Gastroenterology Research and Practice |
| title | In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins |
| title_full | In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins |
| title_fullStr | In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins |
| title_full_unstemmed | In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins |
| title_short | In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins |
| title_sort | in situ absorption in rat intestinal tract of solid dispersion of annonaceous acetogenins |
| url | http://dx.doi.org/10.1155/2012/879676 |
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