True Pseudotumors and “Pseudo” – Pseudotumors: A Case Series
Objective: To characterize the clinical and pathological features of 4 patients with histopathology-confirmed idiopathic orbital inflammatory disease (OID) initially diagnosed as an orbital neoplasm and 9 patients with histopathology-confirmed orbital neoplasm that presented as idiopathic OID. Me...
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Philippine Academy of Ophthalmology
2019-12-01
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| Series: | Philippine Journal of Ophthalmology |
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| Online Access: | https://paojournal.com/index.php/pjo/article/view/132 |
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| author | Maria Donna Damo Santiago, MD, MBA Andrei Paolo S. Angbue-Te, MD |
| author_facet | Maria Donna Damo Santiago, MD, MBA Andrei Paolo S. Angbue-Te, MD |
| author_sort | Maria Donna Damo Santiago, MD, MBA |
| collection | DOAJ |
| description | Objective: To characterize the clinical and pathological features of 4 patients with histopathology-confirmed idiopathic orbital inflammatory disease (OID) initially diagnosed as an orbital neoplasm and 9 patients with histopathology-confirmed orbital neoplasm that presented as idiopathic OID.
Methods: The medical records of 13 patients with orbital mass were reviewed. All biopsies were performed by one orbit surgeon.
Results: There were 4 patients in the histopathology-confirmed idiopathic OID group with preoperative diagnosis of orbital neoplasm. Mean age at presentation was 27 years. Follow-up period ranged from 6 to 41 months. The left orbit was predominantly involved (3/4). The presenting symptoms and signs included proptosis (2/4), diplopia (1/4), and inflammation (1/4). The preoperative best-corrected decimal acuity mean was 0.92. Three of 4 patients retained their preoperative visual acuity postoperatively. There was recurrence of inflammatory signs in only 1 patient, which responded well to oral corticosteroids. In the histopathology-confirmed orbital neoplasm with preoperative diagnosis of idiopathic OID group, there were 9 patients with mean age at presentation of 52 years. Follow-up period averaged 7.5 months (range: 0.5 - 83 months). The presenting symptoms and signs included proptosis (4/9), inflammation (3/9), orbital pain (1/9), and epiphora (1/9). The preoperative best-corrected decimal acuity mean was 0.78. Histopathology and immunohistochemistry of the orbital masses revealed malignancy in 80% (7/9) of these cases.
Conclusions: Idiopathic OID remains a diagnostic dilemma for many physicians. A detailed history, comprehensive physical examination, and appropriate radiological evaluation are essential to differentiate OID and non-inflammatory orbital conditions such as neoplasms. Biopsy is recommended when there is poor or equivocal response to steroids or suspicion of orbital malignancy. |
| format | Article |
| id | doaj-art-d06d123dc2d047f2aedf90a1d95c6331 |
| institution | OA Journals |
| issn | 0031-7659 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-d06d123dc2d047f2aedf90a1d95c63312025-08-20T02:04:49ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592019-12-014427585132True Pseudotumors and “Pseudo” – Pseudotumors: A Case SeriesMaria Donna Damo Santiago, MD, MBA0Andrei Paolo S. Angbue-Te, MD1Department of Ophthalmology, Far Eastern University-Nicanor Reyes Memorial Foundation (FEU-NRMF), Quezon City, Philippines; Department of Ophthalmology, Makati Medical Center, Makati City, Philippines; Department of Ophthalmology, St. Luke’s Medical Center, Quezon City, PhilippinesDepartment of Ophthalmology, Far Eastern University-Nicanor Reyes Memorial Foundation (FEU-NRMF), Quezon City, Philippines; Department of Ophthalmology, Metropolitan Medical Center, Manila, PhilippinesObjective: To characterize the clinical and pathological features of 4 patients with histopathology-confirmed idiopathic orbital inflammatory disease (OID) initially diagnosed as an orbital neoplasm and 9 patients with histopathology-confirmed orbital neoplasm that presented as idiopathic OID. Methods: The medical records of 13 patients with orbital mass were reviewed. All biopsies were performed by one orbit surgeon. Results: There were 4 patients in the histopathology-confirmed idiopathic OID group with preoperative diagnosis of orbital neoplasm. Mean age at presentation was 27 years. Follow-up period ranged from 6 to 41 months. The left orbit was predominantly involved (3/4). The presenting symptoms and signs included proptosis (2/4), diplopia (1/4), and inflammation (1/4). The preoperative best-corrected decimal acuity mean was 0.92. Three of 4 patients retained their preoperative visual acuity postoperatively. There was recurrence of inflammatory signs in only 1 patient, which responded well to oral corticosteroids. In the histopathology-confirmed orbital neoplasm with preoperative diagnosis of idiopathic OID group, there were 9 patients with mean age at presentation of 52 years. Follow-up period averaged 7.5 months (range: 0.5 - 83 months). The presenting symptoms and signs included proptosis (4/9), inflammation (3/9), orbital pain (1/9), and epiphora (1/9). The preoperative best-corrected decimal acuity mean was 0.78. Histopathology and immunohistochemistry of the orbital masses revealed malignancy in 80% (7/9) of these cases. Conclusions: Idiopathic OID remains a diagnostic dilemma for many physicians. A detailed history, comprehensive physical examination, and appropriate radiological evaluation are essential to differentiate OID and non-inflammatory orbital conditions such as neoplasms. Biopsy is recommended when there is poor or equivocal response to steroids or suspicion of orbital malignancy.https://paojournal.com/index.php/pjo/article/view/132pseudotumororbital inflammatory diseaseneoplasmbiopsyhistopathology |
| spellingShingle | Maria Donna Damo Santiago, MD, MBA Andrei Paolo S. Angbue-Te, MD True Pseudotumors and “Pseudo” – Pseudotumors: A Case Series Philippine Journal of Ophthalmology pseudotumor orbital inflammatory disease neoplasm biopsy histopathology |
| title | True Pseudotumors and “Pseudo” – Pseudotumors: A Case Series |
| title_full | True Pseudotumors and “Pseudo” – Pseudotumors: A Case Series |
| title_fullStr | True Pseudotumors and “Pseudo” – Pseudotumors: A Case Series |
| title_full_unstemmed | True Pseudotumors and “Pseudo” – Pseudotumors: A Case Series |
| title_short | True Pseudotumors and “Pseudo” – Pseudotumors: A Case Series |
| title_sort | true pseudotumors and pseudo pseudotumors a case series |
| topic | pseudotumor orbital inflammatory disease neoplasm biopsy histopathology |
| url | https://paojournal.com/index.php/pjo/article/view/132 |
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