Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial

Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial

Background: Persistent Pulmonary Hypertension of the newborn (PPHN) is characterized by sustained elevated Pulmonary Artery Pressure (PAP). Drug resistance and the adverse effects of current therapeutic agents warrant investigation of other targeted therapies. Bosentan has shown benefits in affected...

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Bibliographic Details
Main Authors: Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama Dabbagh
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pediatrics and Neonatology
Subjects:
Bosentan
Macitentan
Sildenafil
Persistent pulmonary hypertension
Randomized controlled trial
Pulmonary artery pressure
Online Access:http://www.sciencedirect.com/science/article/pii/S1875957224000779
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