Impact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomy
Abstract In this study, we investigated the effect of severe dysphagia on the overall survival of patients who underwent PEG. A cohort of patients who underwent PEG between April 2016 and April 2021 was retrospectively analyzed. The Hyodo–Komagane score was used to evaluate swallowing via endoscopy....
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-88097-y |
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| author | Kazumi Shimamoto Ryota Matsui Yorihiro Nishiyama Kyohei Nishino Hiromitsu Ban |
| author_facet | Kazumi Shimamoto Ryota Matsui Yorihiro Nishiyama Kyohei Nishino Hiromitsu Ban |
| author_sort | Kazumi Shimamoto |
| collection | DOAJ |
| description | Abstract In this study, we investigated the effect of severe dysphagia on the overall survival of patients who underwent PEG. A cohort of patients who underwent PEG between April 2016 and April 2021 was retrospectively analyzed. The Hyodo–Komagane score was used to evaluate swallowing via endoscopy. Patients with a Hyodo–Komagane score ≤ 8 were defined as having moderate dysphagia, whereas those with a score ≥ 9 were defined as having severe dysphagia. The primary outcome was overall survival. The prognostic factors were identified using multivariate analysis with the Cox proportional hazards model. Values of p < 0.05 were considered statistically significant. Among the 107 patients, 60 (56.1%) were classified into the moderate dysphagia group and 47 (43.9%) into the severe dysphagia group. The median follow-up period was 16.7 months. The overall survival was significantly worse in the severe group than in the moderate group (p < 0.0001). A multivariate analysis revealed that severe dysphagia was an independent poor prognostic factor (hazard ratio, 2.956; 95% confidence interval, 1.592–5.489; p < 0.001). Aspiration-related pneumonia was most common causes of death after PEG. Severe dysphagia was identified as an independent poor prognostic factor for survival in patients who underwent PEG. |
| format | Article |
| id | doaj-art-d053d1cff3ba4b59b3b072263a723f4b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-d053d1cff3ba4b59b3b072263a723f4b2025-02-02T12:22:27ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-025-88097-yImpact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomyKazumi Shimamoto0Ryota Matsui1Yorihiro Nishiyama2Kyohei Nishino3Hiromitsu Ban4Department of Gastroenterology, Omi Medical CenterDepartment of Gastroenterological Surgery, The Cancer Institute Hospital of JFCRDepartment of Gastroenterology, Omi Medical CenterDepartment of Gastroenterology, Omi Medical CenterDepartment of Gastroenterology, Omi Medical CenterAbstract In this study, we investigated the effect of severe dysphagia on the overall survival of patients who underwent PEG. A cohort of patients who underwent PEG between April 2016 and April 2021 was retrospectively analyzed. The Hyodo–Komagane score was used to evaluate swallowing via endoscopy. Patients with a Hyodo–Komagane score ≤ 8 were defined as having moderate dysphagia, whereas those with a score ≥ 9 were defined as having severe dysphagia. The primary outcome was overall survival. The prognostic factors were identified using multivariate analysis with the Cox proportional hazards model. Values of p < 0.05 were considered statistically significant. Among the 107 patients, 60 (56.1%) were classified into the moderate dysphagia group and 47 (43.9%) into the severe dysphagia group. The median follow-up period was 16.7 months. The overall survival was significantly worse in the severe group than in the moderate group (p < 0.0001). A multivariate analysis revealed that severe dysphagia was an independent poor prognostic factor (hazard ratio, 2.956; 95% confidence interval, 1.592–5.489; p < 0.001). Aspiration-related pneumonia was most common causes of death after PEG. Severe dysphagia was identified as an independent poor prognostic factor for survival in patients who underwent PEG.https://doi.org/10.1038/s41598-025-88097-y |
| spellingShingle | Kazumi Shimamoto Ryota Matsui Yorihiro Nishiyama Kyohei Nishino Hiromitsu Ban Impact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomy Scientific Reports |
| title | Impact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomy |
| title_full | Impact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomy |
| title_fullStr | Impact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomy |
| title_full_unstemmed | Impact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomy |
| title_short | Impact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomy |
| title_sort | impact of severe dysphagia on overall survival after percutaneous endoscopic gastrostomy |
| url | https://doi.org/10.1038/s41598-025-88097-y |
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