Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment
Long coronavirus disease 2019 (LC19) represents a complex global health challenge. Survivors frequently report persistent problems like widespread pain syndrome (WPS), cognitive dysfunction, cardiovascular complications, and sleep disturbances. These health problems, which are worsened by oxidative...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pain Research |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2025.1609095/full |
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| author | Amine Souissi Pablo Prieto-González Helmi Ben Saad |
| author_facet | Amine Souissi Pablo Prieto-González Helmi Ben Saad |
| author_sort | Amine Souissi |
| collection | DOAJ |
| description | Long coronavirus disease 2019 (LC19) represents a complex global health challenge. Survivors frequently report persistent problems like widespread pain syndrome (WPS), cognitive dysfunction, cardiovascular complications, and sleep disturbances. These health problems, which are worsened by oxidative stress and inflammaging, open the prospect of treatment strategies targeting these mechanisms. Melatonin is a potential option for treating LC19 problems because of its anti-inflammatory, antioxidant, and pain-modulating properties. Melatonin targets shared pathological pathways, offering a promising approach to reducing inflammation, oxidative stress, and neuroendocrine dysfunction. The present mini-review explores the therapeutic potential of melatonin in the treatment of LC19, focusing on its effects on WPS and inflammation. |
| format | Article |
| id | doaj-art-d05160bcb49d489580d6b4e1935de875 |
| institution | OA Journals |
| issn | 2673-561X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj-art-d05160bcb49d489580d6b4e1935de8752025-08-20T02:34:39ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2025-06-01610.3389/fpain.2025.16090951609095Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatmentAmine Souissi0Pablo Prieto-González1Helmi Ben Saad2Faculté de Médecine de Sousse, Hôpital Farhat HACHED, Laboratoire de Recherche (Insuffisance Cardiaque, LR12SP09), Université de Sousse, Sousse, TunisieSport Sciences and Diagnostics Research Group, GSD-HPE Department, Prince Sultan University, Riyadh, Saudi ArabiaFaculté de Médecine de Sousse, Hôpital Farhat HACHED, Laboratoire de Recherche (Insuffisance Cardiaque, LR12SP09), Université de Sousse, Sousse, TunisieLong coronavirus disease 2019 (LC19) represents a complex global health challenge. Survivors frequently report persistent problems like widespread pain syndrome (WPS), cognitive dysfunction, cardiovascular complications, and sleep disturbances. These health problems, which are worsened by oxidative stress and inflammaging, open the prospect of treatment strategies targeting these mechanisms. Melatonin is a potential option for treating LC19 problems because of its anti-inflammatory, antioxidant, and pain-modulating properties. Melatonin targets shared pathological pathways, offering a promising approach to reducing inflammation, oxidative stress, and neuroendocrine dysfunction. The present mini-review explores the therapeutic potential of melatonin in the treatment of LC19, focusing on its effects on WPS and inflammation.https://www.frontiersin.org/articles/10.3389/fpain.2025.1609095/fullantioxidantschronic paininflammaginglong COVID-19melatoninoxidative stress |
| spellingShingle | Amine Souissi Pablo Prieto-González Helmi Ben Saad Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment Frontiers in Pain Research antioxidants chronic pain inflammaging long COVID-19 melatonin oxidative stress |
| title | Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment |
| title_full | Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment |
| title_fullStr | Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment |
| title_full_unstemmed | Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment |
| title_short | Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment |
| title_sort | widespread pain syndrome in long covid 19 melatonin as an adjuvant treatment |
| topic | antioxidants chronic pain inflammaging long COVID-19 melatonin oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2025.1609095/full |
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