Predicting immunotherapy prognosis and targeted therapy sensitivity of colon cancer based on a CAF-related molecular signature

Predicting immunotherapy prognosis and targeted therapy sensitivity of colon cancer based on a CAF-related molecular signature

Abstract The role of cancer-associated fibroblasts (CAFs) in modulating the tumor microenvironment (TME) is gaining attention, yet their impact on prognosis and therapeutic response in colon cancer remains unclear. Here, we identified genes associated with CAF infiltration via weighted gene co-expre...

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Bibliographic Details
Main Authors: Leqian Ying, Lu Zhang, Yanping Chen, Chunchun Huang, Jingyi Zhou, Jinbing Xie, Lin Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Colon cancer
Cancer-associated fibroblasts
Tumor microenvironment
Molecular signature
Immune checkpoint Blockade
Online Access:https://doi.org/10.1038/s41598-025-90899-z
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