Unmasking Cryoglobulinemia: A Cold-Blooded Complication of Hepatitis C
A 43-year-old man presents to the hospital with two weeks of persistent fevers, accompanied by myalgias, hematochezia, and abdominal pain. Acute infectious causes were ruled out, and elevated inflammatory markers suggested inflammatory diarrhea or autoimmune conditions. Esophagogastroduodenoscopy (E...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/crhe/8382433 |
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| author | Alexandra M. Arges Ari Levine |
| author_facet | Alexandra M. Arges Ari Levine |
| author_sort | Alexandra M. Arges |
| collection | DOAJ |
| description | A 43-year-old man presents to the hospital with two weeks of persistent fevers, accompanied by myalgias, hematochezia, and abdominal pain. Acute infectious causes were ruled out, and elevated inflammatory markers suggested inflammatory diarrhea or autoimmune conditions. Esophagogastroduodenoscopy (EGD) and colonoscopy were negative. Further testing showed positive antinuclear antibodies (ANAs), ribonucleoprotein (RNP), rheumatoid factor (RF), and hepatitis C virus (HCV) RNA, suggesting an HCV-associated autoimmune process. Hematuria and neuropathic pain raised suspicion for mixed cryoglobulinemia secondary to HCV, supported by low complement levels. Treatment started with prednisone. Cryoglobulins came back positive, confirming mixed cryoglobulinemia secondary to HCV. The patient was referred to the hepatology clinic for antiviral treatment, where he completed treatment, with symptoms resolving, except for his neuropathy. |
| format | Article |
| id | doaj-art-d04bd630a37c4ca0b32d5cd3e4de1a53 |
| institution | Kabale University |
| issn | 2090-6595 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-d04bd630a37c4ca0b32d5cd3e4de1a532025-08-20T03:32:08ZengWileyCase Reports in Hepatology2090-65952025-01-01202510.1155/crhe/8382433Unmasking Cryoglobulinemia: A Cold-Blooded Complication of Hepatitis CAlexandra M. Arges0Ari Levine1Department of MedicineDepartment of MedicineA 43-year-old man presents to the hospital with two weeks of persistent fevers, accompanied by myalgias, hematochezia, and abdominal pain. Acute infectious causes were ruled out, and elevated inflammatory markers suggested inflammatory diarrhea or autoimmune conditions. Esophagogastroduodenoscopy (EGD) and colonoscopy were negative. Further testing showed positive antinuclear antibodies (ANAs), ribonucleoprotein (RNP), rheumatoid factor (RF), and hepatitis C virus (HCV) RNA, suggesting an HCV-associated autoimmune process. Hematuria and neuropathic pain raised suspicion for mixed cryoglobulinemia secondary to HCV, supported by low complement levels. Treatment started with prednisone. Cryoglobulins came back positive, confirming mixed cryoglobulinemia secondary to HCV. The patient was referred to the hepatology clinic for antiviral treatment, where he completed treatment, with symptoms resolving, except for his neuropathy.http://dx.doi.org/10.1155/crhe/8382433 |
| spellingShingle | Alexandra M. Arges Ari Levine Unmasking Cryoglobulinemia: A Cold-Blooded Complication of Hepatitis C Case Reports in Hepatology |
| title | Unmasking Cryoglobulinemia: A Cold-Blooded Complication of Hepatitis C |
| title_full | Unmasking Cryoglobulinemia: A Cold-Blooded Complication of Hepatitis C |
| title_fullStr | Unmasking Cryoglobulinemia: A Cold-Blooded Complication of Hepatitis C |
| title_full_unstemmed | Unmasking Cryoglobulinemia: A Cold-Blooded Complication of Hepatitis C |
| title_short | Unmasking Cryoglobulinemia: A Cold-Blooded Complication of Hepatitis C |
| title_sort | unmasking cryoglobulinemia a cold blooded complication of hepatitis c |
| url | http://dx.doi.org/10.1155/crhe/8382433 |
| work_keys_str_mv | AT alexandramarges unmaskingcryoglobulinemiaacoldbloodedcomplicationofhepatitisc AT arilevine unmaskingcryoglobulinemiaacoldbloodedcomplicationofhepatitisc |