Targeting the disrupted Hippo signaling to prevent neoplastic renal epithelial cell immune evasion

Targeting the disrupted Hippo signaling to prevent neoplastic renal epithelial cell immune evasion

Abstract Large-scale cancer genetic/genomic studies demonstrated that papillary renal cell carcinoma (pRCC) is featured with a frequent shallow deletion of the upstream tumor suppressors of the Hippo/YAP signaling pathway, suggesting that this signaling pathway may play a role in pRCC development. H...

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Main Authors: Xiangmin Lv, Jiyuan Liu, Jinpeng Ruan, Peichao Chen, Chunbo He, Xingeng Zhao, Cong Huang, Li Chen, Hongbo Wang, Guohua Hua, Davie Shi, Siyi Yang, Madelyn L. Moness, Isabelle Montoute, Anjali Dhar, Xingcheng Chen, Raj Kumar, Lu Hu, Ruslan Sadreyev, Oladapo Yeku, Xu Wu, John S. Davis, Cheng Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57697-7
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