Tumor-infiltrating lymphocytes are the key determinants of pathological features associated with pathogenic BRCA variants in high-grade serous ovarian carcinoma

Tumor-infiltrating lymphocytes are the key determinants of pathological features associated with pathogenic BRCA variants in high-grade serous ovarian carcinoma

BackgroundHigh-grade serous ovarian carcinoma (HGSOC), an aggressive cancer associated with pathogenic BRCA variants, causes genomic instability and sensitivity to poly (ADP-ribose) polymerase inhibitors. Identifying pathogenic BRCA variants is crucial for the treatment of HGSOC; however, genetic te...

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Bibliographic Details
Main Authors: Dang H. Nguyen-Phan, Tin Dang, Anh N. Dang, Loc T. H. Huynh, Phuong T. B. Nguyen, Vu Q. Tran, Hanh T. T. Ngo, Thao T. P. Doan, Tu A. Thai, Chien-Chin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Medicine
Subjects:
BRCA
histology
high-grade serous ovarian carcinoma
mitosis
ovary
tumor infiltrating lymphocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1555883/full
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