Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.

Mass drug administration (MDA) programmes against Onchocerca volvulus use ivermectin (IVM) which targets microfilariae (MF), the worm's offspring. Most infected individuals are hyporesponsive and present regulated immune responses despite high parasite burden. Recently, with MDA programmes, the...

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Main Authors: Kathrin Arndts, Sabine Specht, Alexander Y Debrah, Francesca Tamarozzi, Ute Klarmann Schulz, Sabine Mand, Linda Batsa, Alexander Kwarteng, Mark Taylor, Ohene Adjei, Coralie Martin, Laura E Layland, Achim Hoerauf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002679&type=printable
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