Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin

Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin

Inhibition of beta-site APP cleaving enzyme1 (BACE1) is one of the most promising therapeutic approaches for Alzheimer’s disease. To find natural products for the treatment of Alzheimer's disease, absorption, distribution, metabolism, excretion and toxicity (ADMET) properties and in vitro BACE1...

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Bibliographic Details
Main Authors: Zhipeng Yu, Sijia Wu, Wenzhu Zhao, Long Ding, David Shiuan, Fuping Zheng, Jianrong Li, Jingbo Liu
Format: Article
Language:English
Published: Tsinghua University Press 2020-06-01
Series:Food Science and Human Wellness
Subjects:
Alzheimer’s disease
BACE1
ADMET prediction
Molecular docking
Molecular dynamics
KLPGF
Online Access:http://www.sciencedirect.com/science/article/pii/S2213453019301740
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