Anti-Retroviral Strategies for AIDS and Related Diseases
The replication cycle of human immunodeficiency virus type 1 (HIV-1) and other retroviruses consists of four stages: attachment of the virus to specific receptors on the cell surface; uncoating of the viral nucleic acid and conversion to DNA; production of viral RNA and proteins; and assembly and li...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1991-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1991/487657 |
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| _version_ | 1832549333984083968 |
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| author | Mark A Wainberg Andre Dascal Jack Mendelson |
| author_facet | Mark A Wainberg Andre Dascal Jack Mendelson |
| author_sort | Mark A Wainberg |
| collection | DOAJ |
| description | The replication cycle of human immunodeficiency virus type 1 (HIV-1) and other retroviruses consists of four stages: attachment of the virus to specific receptors on the cell surface; uncoating of the viral nucleic acid and conversion to DNA; production of viral RNA and proteins; and assembly and liberation of progeny virus from the cell. Each of these steps represents a potential target for antiviral chemotherapy. Combinations of drugs which act against different steps in the viral replication cycle might be expected to have synergistic potential. Zidovudine (AZT) is the most widely used drug to date for impeding the replication of HIV-1. Although AZT therapy has been reasonably successful, it has not been free from toxicity. In addition, there have been several reports of isolation of AZT-resistant variants of HIV-1. |
| format | Article |
| id | doaj-art-d0423e72d50b4f509afe208a52013454 |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1991-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-d0423e72d50b4f509afe208a520134542025-02-03T06:11:39ZengWileyCanadian Journal of Infectious Diseases1180-23321991-01-012312112810.1155/1991/487657Anti-Retroviral Strategies for AIDS and Related DiseasesMark A Wainberg0Andre Dascal1Jack Mendelson2Sir Mortimer B Davis – Jewish General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaSir Mortimer B Davis – Jewish General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaSir Mortimer B Davis – Jewish General Hospital and McGill AIDS Centre, McGill University, Montreal, Quebec, CanadaThe replication cycle of human immunodeficiency virus type 1 (HIV-1) and other retroviruses consists of four stages: attachment of the virus to specific receptors on the cell surface; uncoating of the viral nucleic acid and conversion to DNA; production of viral RNA and proteins; and assembly and liberation of progeny virus from the cell. Each of these steps represents a potential target for antiviral chemotherapy. Combinations of drugs which act against different steps in the viral replication cycle might be expected to have synergistic potential. Zidovudine (AZT) is the most widely used drug to date for impeding the replication of HIV-1. Although AZT therapy has been reasonably successful, it has not been free from toxicity. In addition, there have been several reports of isolation of AZT-resistant variants of HIV-1.http://dx.doi.org/10.1155/1991/487657 |
| spellingShingle | Mark A Wainberg Andre Dascal Jack Mendelson Anti-Retroviral Strategies for AIDS and Related Diseases Canadian Journal of Infectious Diseases |
| title | Anti-Retroviral Strategies for AIDS and Related Diseases |
| title_full | Anti-Retroviral Strategies for AIDS and Related Diseases |
| title_fullStr | Anti-Retroviral Strategies for AIDS and Related Diseases |
| title_full_unstemmed | Anti-Retroviral Strategies for AIDS and Related Diseases |
| title_short | Anti-Retroviral Strategies for AIDS and Related Diseases |
| title_sort | anti retroviral strategies for aids and related diseases |
| url | http://dx.doi.org/10.1155/1991/487657 |
| work_keys_str_mv | AT markawainberg antiretroviralstrategiesforaidsandrelateddiseases AT andredascal antiretroviralstrategiesforaidsandrelateddiseases AT jackmendelson antiretroviralstrategiesforaidsandrelateddiseases |