A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue
Beiging of adipocytes is characteristic of a higher number of mitochondria, the central hub of metabolism in the cell. However, studies show that beiging can improve metabolic health or cause metabolic disorders. Here we discuss a liver-fat crosstalk for iron flux associated with healthy beiging of...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Autophagy Reports |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/27694127.2024.2396696 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850168744927559680 |
|---|---|
| author | Jinying Yang Limin Shi Anna L. Cubito James F. Collins Zhiyong Cheng |
| author_facet | Jinying Yang Limin Shi Anna L. Cubito James F. Collins Zhiyong Cheng |
| author_sort | Jinying Yang |
| collection | DOAJ |
| description | Beiging of adipocytes is characteristic of a higher number of mitochondria, the central hub of metabolism in the cell. However, studies show that beiging can improve metabolic health or cause metabolic disorders. Here we discuss a liver-fat crosstalk for iron flux associated with healthy beiging of adipocytes. Deletion of the transcription factor FoxO1 in adipocytes (adO1KO mice) induces a higher iron flux from the liver to white adipose tissue, concurrent with augmented mitochondrial biogenesis that increases iron demands. In addition, adO1KO mice adopt an alternate mechanism to sustain mitophagy, which enhances mitochondrial quality control, thereby improving mitochondrial respiratory capacity and metabolic health. However, the liver-fat crosstalk is not detectable in adipose Atg7 knockout (ad7KO) mice, which undergo beiging of adipocytes but have metabolic dysregulation. Autophagic clearance of mitochondria is blocked in ad7KO mice, which accumulates dysfunctional mitochondria and elevates mitochondrial content but lowers mitochondrial respiratory capacity. Mitochondrial biogenesis is comparable in the control and ad7KO mice, and the iron influx into adipocytes and iron efflux from the liver remain unchanged. Therefore, activation of the liver-fat crosstalk is critical for mitochondrial quality control that underlies healthy beiging of adipocytes. |
| format | Article |
| id | doaj-art-d03c361b368b4e0ab349e0d0c20093fb |
| institution | OA Journals |
| issn | 2769-4127 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj-art-d03c361b368b4e0ab349e0d0c20093fb2025-08-20T02:20:54ZengTaylor & Francis GroupAutophagy Reports2769-41272024-12-013110.1080/27694127.2024.2396696A liver-fat crosstalk for iron flux during healthy beiging of adipose tissueJinying Yang0Limin Shi1Anna L. Cubito2James F. Collins3Zhiyong Cheng4Food Science and Human Nutrition Department, University of Florida, Gainesville, USAFood Science and Human Nutrition Department, University of Florida, Gainesville, USAFood Science and Human Nutrition Department, University of Florida, Gainesville, USAFood Science and Human Nutrition Department, University of Florida, Gainesville, USAFood Science and Human Nutrition Department, University of Florida, Gainesville, USABeiging of adipocytes is characteristic of a higher number of mitochondria, the central hub of metabolism in the cell. However, studies show that beiging can improve metabolic health or cause metabolic disorders. Here we discuss a liver-fat crosstalk for iron flux associated with healthy beiging of adipocytes. Deletion of the transcription factor FoxO1 in adipocytes (adO1KO mice) induces a higher iron flux from the liver to white adipose tissue, concurrent with augmented mitochondrial biogenesis that increases iron demands. In addition, adO1KO mice adopt an alternate mechanism to sustain mitophagy, which enhances mitochondrial quality control, thereby improving mitochondrial respiratory capacity and metabolic health. However, the liver-fat crosstalk is not detectable in adipose Atg7 knockout (ad7KO) mice, which undergo beiging of adipocytes but have metabolic dysregulation. Autophagic clearance of mitochondria is blocked in ad7KO mice, which accumulates dysfunctional mitochondria and elevates mitochondrial content but lowers mitochondrial respiratory capacity. Mitochondrial biogenesis is comparable in the control and ad7KO mice, and the iron influx into adipocytes and iron efflux from the liver remain unchanged. Therefore, activation of the liver-fat crosstalk is critical for mitochondrial quality control that underlies healthy beiging of adipocytes.https://www.tandfonline.com/doi/10.1080/27694127.2024.2396696Adipose beigingFoxO1Atg7liver-fat crosstalkiron flux |
| spellingShingle | Jinying Yang Limin Shi Anna L. Cubito James F. Collins Zhiyong Cheng A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue Autophagy Reports Adipose beiging FoxO1 Atg7 liver-fat crosstalk iron flux |
| title | A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue |
| title_full | A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue |
| title_fullStr | A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue |
| title_full_unstemmed | A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue |
| title_short | A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue |
| title_sort | liver fat crosstalk for iron flux during healthy beiging of adipose tissue |
| topic | Adipose beiging FoxO1 Atg7 liver-fat crosstalk iron flux |
| url | https://www.tandfonline.com/doi/10.1080/27694127.2024.2396696 |
| work_keys_str_mv | AT jinyingyang aliverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT liminshi aliverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT annalcubito aliverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT jamesfcollins aliverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT zhiyongcheng aliverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT jinyingyang liverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT liminshi liverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT annalcubito liverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT jamesfcollins liverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue AT zhiyongcheng liverfatcrosstalkforironfluxduringhealthybeigingofadiposetissue |