Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions?
Abstract Objective: To evaluate the association between diabetic retinopathy, diabetic kidney disease, and the 10-year risk of atherosclerotic cardiovascular disease in patients with diabetes. Subjects and methods: A cross-sectional study was performed involving patients diagnosed with either type...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Brazilian Society of Endocrinology and Metabolism
2025-05-01
|
| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000201108&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849325605915459584 |
|---|---|
| author | Clara Krummenauer Maraschin Janine Alessi Mateus Augusto dos Reis Gabriela Oliveira Gonçalves Molino Gabriela Heiden Teló Beatriz D. Schaan |
| author_facet | Clara Krummenauer Maraschin Janine Alessi Mateus Augusto dos Reis Gabriela Oliveira Gonçalves Molino Gabriela Heiden Teló Beatriz D. Schaan |
| author_sort | Clara Krummenauer Maraschin |
| collection | DOAJ |
| description | Abstract Objective: To evaluate the association between diabetic retinopathy, diabetic kidney disease, and the 10-year risk of atherosclerotic cardiovascular disease in patients with diabetes. Subjects and methods: A cross-sectional study was performed involving patients diagnosed with either type 1 or type 2 diabetes mellitus. Participants were classified into four groups: DM (patients without diabetes-related complications), DR (patients with diabetic retinopathy only), DKD (patients with diabetic kidney disease only), and DR + DKD (patients with both diabetic retinopathy and diabetic kidney disease). The primary outcome was the 10-year risk assessment for cardiovascular events, calculated using the American Heart Association’s atherosclerotic cardiovascular disease score. Results: A total of 571 patients were selected including 128 with type 1 diabetes (average age of 39.4 ± 15.1 years; 48.4% female) and 443 with type 2 diabetes (average age of 59.5 ± 11.9 years; 66.4% female). Among the participants with type 2 diabetes, the cardiovascular risk was 15.2 ± 14.6% for the DM group, 15.7 ± 10.7% for the DR group, 22.5 ± 16.7% for the DKD group, and 21.5 ± 15.1% for the DR + DKD group, reflecting a significantly higher cardiovascular risk in the groups with renal involvement (P <0.001). For those with type 1 diabetes, the DM group had a risk of 6.1 ± 8.9%, the DR group 8.9 ±11.8%, the DKD group 5.4 ± 8.8%, and the DR + DKD group 6.1 ± 9.5%. The mean difference in risk between the groups was not statistically significant. Conclusion: In patients with type 2 diabetes, those with diabetic kidney disease appeared to have a higher theoretical risk of cardiovascular disease compared to those with only diabetic retinopathy. |
| format | Article |
| id | doaj-art-d03bbe5b679b4eb28aa81f718c884292 |
| institution | Kabale University |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-d03bbe5b679b4eb28aa81f718c8842922025-08-20T03:48:22ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-05-0169210.20945/2359-4292-2024-0258Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions?Clara Krummenauer Maraschinhttps://orcid.org/0000-0003-1728-8103Janine Alessihttps://orcid.org/0000-0003-4311-3307Mateus Augusto dos Reishttps://orcid.org/0000-0003-0510-4506Gabriela Oliveira Gonçalves Molinohttps://orcid.org/0000-0003-2082-2215Gabriela Heiden Telóhttps://orcid.org/0000-0001-9093-383XBeatriz D. Schaanhttps://orcid.org/0000-0002-2128-8387Abstract Objective: To evaluate the association between diabetic retinopathy, diabetic kidney disease, and the 10-year risk of atherosclerotic cardiovascular disease in patients with diabetes. Subjects and methods: A cross-sectional study was performed involving patients diagnosed with either type 1 or type 2 diabetes mellitus. Participants were classified into four groups: DM (patients without diabetes-related complications), DR (patients with diabetic retinopathy only), DKD (patients with diabetic kidney disease only), and DR + DKD (patients with both diabetic retinopathy and diabetic kidney disease). The primary outcome was the 10-year risk assessment for cardiovascular events, calculated using the American Heart Association’s atherosclerotic cardiovascular disease score. Results: A total of 571 patients were selected including 128 with type 1 diabetes (average age of 39.4 ± 15.1 years; 48.4% female) and 443 with type 2 diabetes (average age of 59.5 ± 11.9 years; 66.4% female). Among the participants with type 2 diabetes, the cardiovascular risk was 15.2 ± 14.6% for the DM group, 15.7 ± 10.7% for the DR group, 22.5 ± 16.7% for the DKD group, and 21.5 ± 15.1% for the DR + DKD group, reflecting a significantly higher cardiovascular risk in the groups with renal involvement (P <0.001). For those with type 1 diabetes, the DM group had a risk of 6.1 ± 8.9%, the DR group 8.9 ±11.8%, the DKD group 5.4 ± 8.8%, and the DR + DKD group 6.1 ± 9.5%. The mean difference in risk between the groups was not statistically significant. Conclusion: In patients with type 2 diabetes, those with diabetic kidney disease appeared to have a higher theoretical risk of cardiovascular disease compared to those with only diabetic retinopathy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000201108&lng=en&tlng=enDiabetes mellitusDiabetic nephropathiesDiabetic retinopathyHeart disease risk factors |
| spellingShingle | Clara Krummenauer Maraschin Janine Alessi Mateus Augusto dos Reis Gabriela Oliveira Gonçalves Molino Gabriela Heiden Teló Beatriz D. Schaan Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions? Archives of Endocrinology and Metabolism Diabetes mellitus Diabetic nephropathies Diabetic retinopathy Heart disease risk factors |
| title | Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions? |
| title_full | Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions? |
| title_fullStr | Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions? |
| title_full_unstemmed | Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions? |
| title_short | Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions? |
| title_sort | diabetic retinopathy and diabetic kidney disease either isolated or associated impact on the 10 year risk of cardiovascular disease are we dealing with similar conditions |
| topic | Diabetes mellitus Diabetic nephropathies Diabetic retinopathy Heart disease risk factors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000201108&lng=en&tlng=en |
| work_keys_str_mv | AT clarakrummenauermaraschin diabeticretinopathyanddiabetickidneydiseaseeitherisolatedorassociatedimpactonthe10yearriskofcardiovasculardiseasearewedealingwithsimilarconditions AT janinealessi diabeticretinopathyanddiabetickidneydiseaseeitherisolatedorassociatedimpactonthe10yearriskofcardiovasculardiseasearewedealingwithsimilarconditions AT mateusaugustodosreis diabeticretinopathyanddiabetickidneydiseaseeitherisolatedorassociatedimpactonthe10yearriskofcardiovasculardiseasearewedealingwithsimilarconditions AT gabrielaoliveiragoncalvesmolino diabeticretinopathyanddiabetickidneydiseaseeitherisolatedorassociatedimpactonthe10yearriskofcardiovasculardiseasearewedealingwithsimilarconditions AT gabrielaheidentelo diabeticretinopathyanddiabetickidneydiseaseeitherisolatedorassociatedimpactonthe10yearriskofcardiovasculardiseasearewedealingwithsimilarconditions AT beatrizdschaan diabeticretinopathyanddiabetickidneydiseaseeitherisolatedorassociatedimpactonthe10yearriskofcardiovasculardiseasearewedealingwithsimilarconditions |