Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study
The prevalence of obesity is increasing rapidly worldwide, particularly in Asia. Visceral obesity, characterized by intra-abdominal fat accumulation, is a precursor to metabolic syndrome, encompassing hyperglycemia, dyslipidemia, and hypertension, which elevate the risk of atherosclerosis and cardio...
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The Japan Endocrine Society
2025-05-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/72/5/72_EJ24-0554/_html/-char/en |
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| _version_ | 1850234406621413376 |
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| author | Hajime Nawata Li Ou Xu Zhang Qinglan Song Jing Huang Jin Hu Kazue Ito Shinichi Obo Takeharu Fukushima Kaori Iwami Shizuka Iguchi Ai Igarashi Xiaoyang He Jing Zhang Yu Xia Ken Takasaki |
| author_facet | Hajime Nawata Li Ou Xu Zhang Qinglan Song Jing Huang Jin Hu Kazue Ito Shinichi Obo Takeharu Fukushima Kaori Iwami Shizuka Iguchi Ai Igarashi Xiaoyang He Jing Zhang Yu Xia Ken Takasaki |
| author_sort | Hajime Nawata |
| collection | DOAJ |
| description | The prevalence of obesity is increasing rapidly worldwide, particularly in Asia. Visceral obesity, characterized by intra-abdominal fat accumulation, is a precursor to metabolic syndrome, encompassing hyperglycemia, dyslipidemia, and hypertension, which elevate the risk of atherosclerosis and cardiovascular disease. A visceral fat area (VFA) of ≥100 cm2 is a recognized threshold for diagnosing obesity-related metabolic syndrome. This study aimed to identify independent risk factors for VFA ≥100 cm2 in middle-aged Chinese individuals from the general population. We analyzed data from 148 participants (mean age: 49.3 ± 10.8 years; 54% male) who underwent health check-ups. VFA and subcutaneous fat area were assessed using computed tomography, while arterial stiffness and fatty liver were evaluated via brachial-ankle pulse wave velocity (baPWV) and abdominal ultrasonography, respectively. Between-group comparisons (VFA ≥100 cm2 vs. VFA <100 cm2) were conducted using unpaired t-tests and Mann-Whitney U tests, and logistic regression analysis identified risk factors. Multivariable regression analysis revealed that baPWV ≥1,400 cm/s (odds ratio [OR] = 5.71, p = 0.011), waist circumference ≥85 cm (OR = 5.46, p = 0.026), fasting blood glucose (FBG) ≥100 mg/dL (OR = 5.69, p = 0.030), male sex (OR = 12.79, p = 0.029), and fatty liver (OR = 3.99, p = 0.042) were significant independent risk factors for VFA ≥100 cm2. Among these, baPWV ≥1,400 cm/s was the most significant, showing a positive correlation with VFA (r = 0.365, p < 0.001). Visceral obesity (VFA ≥100 cm2) is a critical target for interventions addressing metabolic syndrome, metabolic dysfunction-associated fatty liver disease (MAFLD), and cardiovascular disease, particularly in males. |
| format | Article |
| id | doaj-art-d038f7b267f24d598353ff3fd3cf39fd |
| institution | OA Journals |
| issn | 1348-4540 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-d038f7b267f24d598353ff3fd3cf39fd2025-08-20T02:02:39ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402025-05-0172552553310.1507/endocrj.EJ24-0554endocrjArterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional studyHajime Nawata0Li Ou1Xu Zhang2Qinglan Song3Jing Huang4Jin Hu5Kazue Ito6Shinichi Obo7Takeharu Fukushima8Kaori Iwami9Shizuka Iguchi10Ai Igarashi11Xiaoyang He12Jing Zhang13Yu Xia14Ken Takasaki15Zhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaZhichengheai Health Management Center, Leading Center, Tianfu Chengdu 610000, ChinaThe prevalence of obesity is increasing rapidly worldwide, particularly in Asia. Visceral obesity, characterized by intra-abdominal fat accumulation, is a precursor to metabolic syndrome, encompassing hyperglycemia, dyslipidemia, and hypertension, which elevate the risk of atherosclerosis and cardiovascular disease. A visceral fat area (VFA) of ≥100 cm2 is a recognized threshold for diagnosing obesity-related metabolic syndrome. This study aimed to identify independent risk factors for VFA ≥100 cm2 in middle-aged Chinese individuals from the general population. We analyzed data from 148 participants (mean age: 49.3 ± 10.8 years; 54% male) who underwent health check-ups. VFA and subcutaneous fat area were assessed using computed tomography, while arterial stiffness and fatty liver were evaluated via brachial-ankle pulse wave velocity (baPWV) and abdominal ultrasonography, respectively. Between-group comparisons (VFA ≥100 cm2 vs. VFA <100 cm2) were conducted using unpaired t-tests and Mann-Whitney U tests, and logistic regression analysis identified risk factors. Multivariable regression analysis revealed that baPWV ≥1,400 cm/s (odds ratio [OR] = 5.71, p = 0.011), waist circumference ≥85 cm (OR = 5.46, p = 0.026), fasting blood glucose (FBG) ≥100 mg/dL (OR = 5.69, p = 0.030), male sex (OR = 12.79, p = 0.029), and fatty liver (OR = 3.99, p = 0.042) were significant independent risk factors for VFA ≥100 cm2. Among these, baPWV ≥1,400 cm/s was the most significant, showing a positive correlation with VFA (r = 0.365, p < 0.001). Visceral obesity (VFA ≥100 cm2) is a critical target for interventions addressing metabolic syndrome, metabolic dysfunction-associated fatty liver disease (MAFLD), and cardiovascular disease, particularly in males.https://www.jstage.jst.go.jp/article/endocrj/72/5/72_EJ24-0554/_html/-char/envisceral obesityarterial stiffnessmetabolic syndromemetabolic dysfunction-associated fatty liver disease (mafld)cardiovascular disease |
| spellingShingle | Hajime Nawata Li Ou Xu Zhang Qinglan Song Jing Huang Jin Hu Kazue Ito Shinichi Obo Takeharu Fukushima Kaori Iwami Shizuka Iguchi Ai Igarashi Xiaoyang He Jing Zhang Yu Xia Ken Takasaki Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study Endocrine Journal visceral obesity arterial stiffness metabolic syndrome metabolic dysfunction-associated fatty liver disease (mafld) cardiovascular disease |
| title | Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study |
| title_full | Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study |
| title_fullStr | Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study |
| title_full_unstemmed | Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study |
| title_short | Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study |
| title_sort | arterial stiffness high fasting glucose and fatty liver as risk factors for visceral obesity in middle aged chinese individuals a cross sectional study |
| topic | visceral obesity arterial stiffness metabolic syndrome metabolic dysfunction-associated fatty liver disease (mafld) cardiovascular disease |
| url | https://www.jstage.jst.go.jp/article/endocrj/72/5/72_EJ24-0554/_html/-char/en |
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