Size matters: a review of the challenges in and importance of multimodal approaches to the management of patients with small, node-negative, triple-negative breast cancer
Patients diagnosed with small (T1a-c) node-negative triple-negative breast cancer (TNBC) comprise an understudied population. These patients have been commonly excluded from participation in large, practice-changing clinical trials that establish improvements in disease-free and overall survival due...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1465147/full |
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| author | Vishnu Prasath Vishnu Prasath Briana To Briana To Dionisia M. Quiroga Bridget A. Oppong Kai Johnson Benjin Facer Robert Wesolowski |
| author_facet | Vishnu Prasath Vishnu Prasath Briana To Briana To Dionisia M. Quiroga Bridget A. Oppong Kai Johnson Benjin Facer Robert Wesolowski |
| author_sort | Vishnu Prasath |
| collection | DOAJ |
| description | Patients diagnosed with small (T1a-c) node-negative triple-negative breast cancer (TNBC) comprise an understudied population. These patients have been commonly excluded from participation in large, practice-changing clinical trials that establish improvements in disease-free and overall survival due to neoadjuvant or adjuvant systemic therapies as well as innovative local therapies. Despite this, patients with small, node-negative TNBC are at higher risk for early relapse compared to patients with hormone receptor-positive breast cancer matched for the same T and N stage. We highlight retrospective and prospective studies that analyze the benefit of chemotherapy in small node-negative TNBC patients. Furthermore, we discuss current guidelines for radiation therapy, surgical management, and relevant studies examining local therapy for patients with early-stage node-negative TNBC. |
| format | Article |
| id | doaj-art-d0363c9c7aca40e295f5d14a85e448db |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-d0363c9c7aca40e295f5d14a85e448db2025-08-20T03:55:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.14651471465147Size matters: a review of the challenges in and importance of multimodal approaches to the management of patients with small, node-negative, triple-negative breast cancerVishnu Prasath0Vishnu Prasath1Briana To2Briana To3Dionisia M. Quiroga4Bridget A. Oppong5Kai Johnson6Benjin Facer7Robert Wesolowski8Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United StatesDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United StatesDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United StatesDivision of Surgical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United StatesDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United StatesDivision of Radiation Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United StatesDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United StatesPatients diagnosed with small (T1a-c) node-negative triple-negative breast cancer (TNBC) comprise an understudied population. These patients have been commonly excluded from participation in large, practice-changing clinical trials that establish improvements in disease-free and overall survival due to neoadjuvant or adjuvant systemic therapies as well as innovative local therapies. Despite this, patients with small, node-negative TNBC are at higher risk for early relapse compared to patients with hormone receptor-positive breast cancer matched for the same T and N stage. We highlight retrospective and prospective studies that analyze the benefit of chemotherapy in small node-negative TNBC patients. Furthermore, we discuss current guidelines for radiation therapy, surgical management, and relevant studies examining local therapy for patients with early-stage node-negative TNBC.https://www.frontiersin.org/articles/10.3389/fonc.2025.1465147/fulltriple-negative breast cancerchemotherapyradiation therapysurgical oncologymultimodal management |
| spellingShingle | Vishnu Prasath Vishnu Prasath Briana To Briana To Dionisia M. Quiroga Bridget A. Oppong Kai Johnson Benjin Facer Robert Wesolowski Size matters: a review of the challenges in and importance of multimodal approaches to the management of patients with small, node-negative, triple-negative breast cancer Frontiers in Oncology triple-negative breast cancer chemotherapy radiation therapy surgical oncology multimodal management |
| title | Size matters: a review of the challenges in and importance of multimodal approaches to the management of patients with small, node-negative, triple-negative breast cancer |
| title_full | Size matters: a review of the challenges in and importance of multimodal approaches to the management of patients with small, node-negative, triple-negative breast cancer |
| title_fullStr | Size matters: a review of the challenges in and importance of multimodal approaches to the management of patients with small, node-negative, triple-negative breast cancer |
| title_full_unstemmed | Size matters: a review of the challenges in and importance of multimodal approaches to the management of patients with small, node-negative, triple-negative breast cancer |
| title_short | Size matters: a review of the challenges in and importance of multimodal approaches to the management of patients with small, node-negative, triple-negative breast cancer |
| title_sort | size matters a review of the challenges in and importance of multimodal approaches to the management of patients with small node negative triple negative breast cancer |
| topic | triple-negative breast cancer chemotherapy radiation therapy surgical oncology multimodal management |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1465147/full |
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