Atherogenic Index of Plasma (AIP): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross‐Sectional Study
ABSTRACT Background This study aimed to evaluate the relationships of conventional and calculated lipid indices with obesity or overweight in patients with type 2 diabetes (T2D). Methods In this cross‐sectional study, all participants were categorised into three groups: normal weight (18 ≤ BMI < ...
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| Format: | Article |
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Wiley
2024-11-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.70007 |
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| author | Sahar Karimpour Reyhan Amirhossein Yadegar Sahar Samimi Pooria Nakhaei Alireza Esteghamati Manouchehr Nakhjavani Soheil Karimpour Reihan Soghra Rabizadeh |
| author_facet | Sahar Karimpour Reyhan Amirhossein Yadegar Sahar Samimi Pooria Nakhaei Alireza Esteghamati Manouchehr Nakhjavani Soheil Karimpour Reihan Soghra Rabizadeh |
| author_sort | Sahar Karimpour Reyhan |
| collection | DOAJ |
| description | ABSTRACT Background This study aimed to evaluate the relationships of conventional and calculated lipid indices with obesity or overweight in patients with type 2 diabetes (T2D). Methods In this cross‐sectional study, all participants were categorised into three groups: normal weight (18 ≤ BMI < 25), overweight (25 ≤ BMI < 30) and obese (BMI ≥ 30). Conventional lipid indices, including triglyceride (TG), total cholesterol, LDL‐C and HDL‐C, were measured. Lipid indices, including the atherogenic index of plasma (AIP), non‐HDL‐C, TC/HDL‐C, LDL‐C/HDL‐C, non‐HLD‐C/HDL‐C (atherogenic index, AI) and lipoprotein combine index (LCI), were calculated. The associations of these lipid indices with obesity and overweight status were evaluated using univariate and multivariate multinomial logistic regression analyses. Results In this study, 2661 patients with T2D, including 651 patients with normal weight, 1144 with overweight, and 866 with obesity, were recruited. According to a multinomial logistic regression analysis after adjustment for multiple confounders, the odds ratio (OR) was greater for the AIP than for other conventional and calculated lipid indices in overweight and obese patients with T2D. The AIP had a significant relationship with overweight, with an OR of 4.79 (95% CI: 1.65–13.85), and it had a significant relationship with obesity, with an OR of 13.64 (95% CI: 3.96–47.04). According to the ROC curve, with a cut‐off value of 0.68, AIP could predict obesity with 82% sensitivity and 55% specificity (AUC = 0.770, 95% CI: 0.729–0.812, p < 0.001). Conclusion Compared with other conventional and calculated lipid markers, the AIP is most strongly associated with obesity and overweight in patients with T2D. |
| format | Article |
| id | doaj-art-d0345b729eb84444a42323d9577e97b0 |
| institution | OA Journals |
| issn | 2398-9238 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj-art-d0345b729eb84444a42323d9577e97b02025-08-20T02:33:08ZengWileyEndocrinology, Diabetes & Metabolism2398-92382024-11-0176n/an/a10.1002/edm2.70007Atherogenic Index of Plasma (AIP): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross‐Sectional StudySahar Karimpour Reyhan0Amirhossein Yadegar1Sahar Samimi2Pooria Nakhaei3Alireza Esteghamati4Manouchehr Nakhjavani5Soheil Karimpour Reihan6Soghra Rabizadeh7Endocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran IranEndocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran IranEndocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran IranEndocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran IranEndocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran IranEndocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran IranMechanical Engineering School University of Tehran Tehran IranEndocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran IranABSTRACT Background This study aimed to evaluate the relationships of conventional and calculated lipid indices with obesity or overweight in patients with type 2 diabetes (T2D). Methods In this cross‐sectional study, all participants were categorised into three groups: normal weight (18 ≤ BMI < 25), overweight (25 ≤ BMI < 30) and obese (BMI ≥ 30). Conventional lipid indices, including triglyceride (TG), total cholesterol, LDL‐C and HDL‐C, were measured. Lipid indices, including the atherogenic index of plasma (AIP), non‐HDL‐C, TC/HDL‐C, LDL‐C/HDL‐C, non‐HLD‐C/HDL‐C (atherogenic index, AI) and lipoprotein combine index (LCI), were calculated. The associations of these lipid indices with obesity and overweight status were evaluated using univariate and multivariate multinomial logistic regression analyses. Results In this study, 2661 patients with T2D, including 651 patients with normal weight, 1144 with overweight, and 866 with obesity, were recruited. According to a multinomial logistic regression analysis after adjustment for multiple confounders, the odds ratio (OR) was greater for the AIP than for other conventional and calculated lipid indices in overweight and obese patients with T2D. The AIP had a significant relationship with overweight, with an OR of 4.79 (95% CI: 1.65–13.85), and it had a significant relationship with obesity, with an OR of 13.64 (95% CI: 3.96–47.04). According to the ROC curve, with a cut‐off value of 0.68, AIP could predict obesity with 82% sensitivity and 55% specificity (AUC = 0.770, 95% CI: 0.729–0.812, p < 0.001). Conclusion Compared with other conventional and calculated lipid markers, the AIP is most strongly associated with obesity and overweight in patients with T2D.https://doi.org/10.1002/edm2.70007atherogenic index of plasmadiabeteslipid indicesobesityoverweight |
| spellingShingle | Sahar Karimpour Reyhan Amirhossein Yadegar Sahar Samimi Pooria Nakhaei Alireza Esteghamati Manouchehr Nakhjavani Soheil Karimpour Reihan Soghra Rabizadeh Atherogenic Index of Plasma (AIP): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross‐Sectional Study Endocrinology, Diabetes & Metabolism atherogenic index of plasma diabetes lipid indices obesity overweight |
| title | Atherogenic Index of Plasma (AIP): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross‐Sectional Study |
| title_full | Atherogenic Index of Plasma (AIP): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross‐Sectional Study |
| title_fullStr | Atherogenic Index of Plasma (AIP): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross‐Sectional Study |
| title_full_unstemmed | Atherogenic Index of Plasma (AIP): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross‐Sectional Study |
| title_short | Atherogenic Index of Plasma (AIP): The Most Accurate Indicator of Overweight and Obesity Among Lipid Indices in Type 2 Diabetes—Findings From a Cross‐Sectional Study |
| title_sort | atherogenic index of plasma aip the most accurate indicator of overweight and obesity among lipid indices in type 2 diabetes findings from a cross sectional study |
| topic | atherogenic index of plasma diabetes lipid indices obesity overweight |
| url | https://doi.org/10.1002/edm2.70007 |
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