NSD2 and miRNAs as Key Regulators of Melanoma Response to Romidepsin and Interferon‐α2b Treatment

NSD2 and miRNAs as Key Regulators of Melanoma Response to Romidepsin and Interferon‐α2b Treatment

ABSTRACT Background We investigated the role of Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and microRNAs (miRNAs) in melanoma de‐differentiation following Romidepsin and Interferon‐α2b (RI) treatment. Melanoma is the most lethal form of skin cancer, and despite advancements in therapy, tre...

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Main Authors: Alessandro De Santis, Lucrezia De Santis, Francesca Rossi, Silvia Gasparini, Valerio Licursi, Vito Antonio Amico, Imerio Capone, Alessandra Fragale, Stefania D'atri, Lucia Gabriele, Carlo Presutti
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Cancer Medicine
Subjects:
epigenetic regulation
melanoma
microRNAs
NSD2
proliferative subtypes
Online Access:https://doi.org/10.1002/cam4.70917
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