Advances regarding Neuroinflammation Biomarkers with Noninvasive Techniques in Epilepsy
A rapidly growing body of evidence supports that neuroinflammation plays a major role in epileptogenesis and disease progression. The capacity to identify pathological neuroinflammation in individuals with epilepsy is a crucial step on the timing of anti-inflammatory intervention and patient selecti...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2021/7946252 |
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| _version_ | 1849695439068069888 |
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| author | Hongrui Ma Hua Lin |
| author_facet | Hongrui Ma Hua Lin |
| author_sort | Hongrui Ma |
| collection | DOAJ |
| description | A rapidly growing body of evidence supports that neuroinflammation plays a major role in epileptogenesis and disease progression. The capacity to identify pathological neuroinflammation in individuals with epilepsy is a crucial step on the timing of anti-inflammatory intervention and patient selection, which will be challenging aspects in future clinical studies. The discovery of noninvasive biomarkers that are accessible in the blood or molecular neuroimaging would facilitate clinical translation of experimental findings into humans. These innovative and noninvasive approaches have the advantage of monitoring the dynamic changes of neuroinflammation in epilepsy. Here, we will review the available evidence for the measurement of neuroinflammation in patients with epilepsy using noninvasive techniques and critically analyze the major scientific challenges of noninvasive methods. Finally, we propose the potential for use in clinical applications. |
| format | Article |
| id | doaj-art-d03038694b6540e39a6f5daf9fe62583 |
| institution | DOAJ |
| issn | 1875-8584 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-d03038694b6540e39a6f5daf9fe625832025-08-20T03:19:46ZengWileyBehavioural Neurology1875-85842021-01-01202110.1155/2021/7946252Advances regarding Neuroinflammation Biomarkers with Noninvasive Techniques in EpilepsyHongrui Ma0Hua Lin1Department of NeurologyDepartment of NeurologyA rapidly growing body of evidence supports that neuroinflammation plays a major role in epileptogenesis and disease progression. The capacity to identify pathological neuroinflammation in individuals with epilepsy is a crucial step on the timing of anti-inflammatory intervention and patient selection, which will be challenging aspects in future clinical studies. The discovery of noninvasive biomarkers that are accessible in the blood or molecular neuroimaging would facilitate clinical translation of experimental findings into humans. These innovative and noninvasive approaches have the advantage of monitoring the dynamic changes of neuroinflammation in epilepsy. Here, we will review the available evidence for the measurement of neuroinflammation in patients with epilepsy using noninvasive techniques and critically analyze the major scientific challenges of noninvasive methods. Finally, we propose the potential for use in clinical applications.http://dx.doi.org/10.1155/2021/7946252 |
| spellingShingle | Hongrui Ma Hua Lin Advances regarding Neuroinflammation Biomarkers with Noninvasive Techniques in Epilepsy Behavioural Neurology |
| title | Advances regarding Neuroinflammation Biomarkers with Noninvasive Techniques in Epilepsy |
| title_full | Advances regarding Neuroinflammation Biomarkers with Noninvasive Techniques in Epilepsy |
| title_fullStr | Advances regarding Neuroinflammation Biomarkers with Noninvasive Techniques in Epilepsy |
| title_full_unstemmed | Advances regarding Neuroinflammation Biomarkers with Noninvasive Techniques in Epilepsy |
| title_short | Advances regarding Neuroinflammation Biomarkers with Noninvasive Techniques in Epilepsy |
| title_sort | advances regarding neuroinflammation biomarkers with noninvasive techniques in epilepsy |
| url | http://dx.doi.org/10.1155/2021/7946252 |
| work_keys_str_mv | AT hongruima advancesregardingneuroinflammationbiomarkerswithnoninvasivetechniquesinepilepsy AT hualin advancesregardingneuroinflammationbiomarkerswithnoninvasivetechniquesinepilepsy |