Melatonin Modulates Endoplasmic Reticulum Stress and Akt/GSK3-Beta Signaling Pathway in a Rat Model of Renal Warm Ischemia Reperfusion

Melatonin Modulates Endoplasmic Reticulum Stress and Akt/GSK3-Beta Signaling Pathway in a Rat Model of Renal Warm Ischemia Reperfusion

Melatonin (Mel) is widely used to attenuate ischemia/reperfusion (I/R) injury in several organs. Nevertheless, the underlying mechanisms remain unclear. This study was conducted to explore the effect of Mel on endoplasmic reticulum (ER) stress, Akt and MAPK cascades after renal warm I/R. Eighteen Wi...

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Main Authors: Kaouther Hadj Ayed Tka, Asma Mahfoudh Boussaid, Mohamed Amine Zaouali, Rym Kammoun, Mohamed Bejaoui, Sonia Ghoul Mazgar, Joan Rosello Catafau, Hassen Ben Abdennebi
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Analytical Cellular Pathology
Online Access:http://dx.doi.org/10.1155/2015/635172
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