Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media
Alum (KAl(SO4)2·12H2O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/716389 |
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| author | Harshita Sachdeva Diksha Dwivedi Rekha Saroj |
| author_facet | Harshita Sachdeva Diksha Dwivedi Rekha Saroj |
| author_sort | Harshita Sachdeva |
| collection | DOAJ |
| description | Alum (KAl(SO4)2·12H2O) is an inexpensive,
efficient, and nontoxic catalyst used for the synthesis of
2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic
acid derivatives in aqueous media by the reaction of 3-acetyl pyridine (1), amino acids (2)/(6),
and thiosemicarbazide (4) at 80°C.
This methodology offers significant improvements for the synthesis of products
with regards to the yield of products, simplicity in operation, and green aspects
by avoiding toxic catalysts which uphold the motto of green chemistry.
Synthesized compounds have been characterized by FT-IR, 13C NMR, and 1HNMR spectroscopy. |
| format | Article |
| id | doaj-art-d02e8433a2ca483ba37ba75113671688 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d02e8433a2ca483ba37ba751136716882025-08-20T03:19:45ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/716389716389Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous MediaHarshita Sachdeva0Diksha Dwivedi1Rekha Saroj2Department of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Lakshmangarh, Sikar, Rajasthan 332311, IndiaDepartment of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Lakshmangarh, Sikar, Rajasthan 332311, IndiaDepartment of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Lakshmangarh, Sikar, Rajasthan 332311, IndiaAlum (KAl(SO4)2·12H2O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl pyridine (1), amino acids (2)/(6), and thiosemicarbazide (4) at 80°C. This methodology offers significant improvements for the synthesis of products with regards to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts which uphold the motto of green chemistry. Synthesized compounds have been characterized by FT-IR, 13C NMR, and 1HNMR spectroscopy.http://dx.doi.org/10.1155/2013/716389 |
| spellingShingle | Harshita Sachdeva Diksha Dwivedi Rekha Saroj Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media The Scientific World Journal |
| title | Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media |
| title_full | Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media |
| title_fullStr | Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media |
| title_full_unstemmed | Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media |
| title_short | Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media |
| title_sort | alum catalyzed simple efficient and green synthesis of 2 3 amino 5 methyl 5 pyridin 3 yl 1 5 dihydro 4h 1 2 4 triazol 4 yl propanoic acid derivatives in aqueous media |
| url | http://dx.doi.org/10.1155/2013/716389 |
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