Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media
Alum (KAl(SO4)2·12H2O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/716389 |
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| Summary: | Alum (KAl(SO4)2·12H2O) is an inexpensive,
efficient, and nontoxic catalyst used for the synthesis of
2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic
acid derivatives in aqueous media by the reaction of 3-acetyl pyridine (1), amino acids (2)/(6),
and thiosemicarbazide (4) at 80°C.
This methodology offers significant improvements for the synthesis of products
with regards to the yield of products, simplicity in operation, and green aspects
by avoiding toxic catalysts which uphold the motto of green chemistry.
Synthesized compounds have been characterized by FT-IR, 13C NMR, and 1HNMR spectroscopy. |
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| ISSN: | 1537-744X |