Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation
Owing to their excellent bioavailability, high bioactivity, and low toxicity, selenium nanoparticles (SeNPs) are emerging nanomaterials. In this study, SeNPs with a size of ∼41.8 nm were synthesised by γ-irradiation using oligochitosan (OCS) as the stabiliser. As-synthesized SeNPs/OCS were character...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/6635022 |
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| author | Duy Ngoc Nguyen Phu Van Dang Quoc Anh Le Lan Thi Kim Nguyen Hien Quoc Nguyen Ngan Thi Thu Tran Ha Le Bao Tran Tuan Dinh Phan Ha Manh Bui |
| author_facet | Duy Ngoc Nguyen Phu Van Dang Quoc Anh Le Lan Thi Kim Nguyen Hien Quoc Nguyen Ngan Thi Thu Tran Ha Le Bao Tran Tuan Dinh Phan Ha Manh Bui |
| author_sort | Duy Ngoc Nguyen |
| collection | DOAJ |
| description | Owing to their excellent bioavailability, high bioactivity, and low toxicity, selenium nanoparticles (SeNPs) are emerging nanomaterials. In this study, SeNPs with a size of ∼41.8 nm were synthesised by γ-irradiation using oligochitosan (OCS) as the stabiliser. As-synthesized SeNPs/OCS were characterised by UV-Vis spectroscopy, transmission electron microscopy, and energy-dispersive X-ray (EDX) analysis. Results revealed that the as-obtained SeNP/OCS powder exhibits high purity. The SeNP/OCS solution’s stability test results indicated that the SeNP/OCS solution stored at 4°C exhibits good stability for 60 days. The SeNP/OCS solution was unstable at ambient temperature, and SeNP/OCS exhibited agglomeration after about 15 days. SeNP/OCS products recovered the total white blood cells of γ-ray irradiated mice. The SeNP/OCS product, which was synthesised by a green approach, with high purity and efficient recuperation of white blood cells, can be used potentially as a functional supplement to assist cancer radiotherapy patients. |
| format | Article |
| id | doaj-art-d02de11bdb4f4e9fbfc445f3c47f0771 |
| institution | OA Journals |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-d02de11bdb4f4e9fbfc445f3c47f07712025-08-20T02:20:03ZengWileyJournal of Chemistry2090-90632090-90712021-01-01202110.1155/2021/66350226635022Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray RadiationDuy Ngoc Nguyen0Phu Van Dang1Quoc Anh Le2Lan Thi Kim Nguyen3Hien Quoc Nguyen4Ngan Thi Thu Tran5Ha Le Bao Tran6Tuan Dinh Phan7Ha Manh Bui8Research and Development Center for Radiation Technology, Vietnam Atomic Energy Institute, 202A, Street 11, Thu Duc District, Ho Chi Minh, VietnamResearch and Development Center for Radiation Technology, Vietnam Atomic Energy Institute, 202A, Street 11, Thu Duc District, Ho Chi Minh, VietnamResearch and Development Center for Radiation Technology, Vietnam Atomic Energy Institute, 202A, Street 11, Thu Duc District, Ho Chi Minh, VietnamVietnam National University Ho Chi Minh City, University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh, VietnamResearch and Development Center for Radiation Technology, Vietnam Atomic Energy Institute, 202A, Street 11, Thu Duc District, Ho Chi Minh, VietnamVietnam National University Ho Chi Minh City, University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh, VietnamVietnam National University Ho Chi Minh City, University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh, VietnamHo Chi Minh City University of Natural Resources and Environment, 236B, Le Van Sy Street, Tan Binh District, Ho Chi Minh, VietnamDepartment of Environmental Science, Saigon University, 273 An Duong Vuong Street, District 5, Ho Chi Minh, VietnamOwing to their excellent bioavailability, high bioactivity, and low toxicity, selenium nanoparticles (SeNPs) are emerging nanomaterials. In this study, SeNPs with a size of ∼41.8 nm were synthesised by γ-irradiation using oligochitosan (OCS) as the stabiliser. As-synthesized SeNPs/OCS were characterised by UV-Vis spectroscopy, transmission electron microscopy, and energy-dispersive X-ray (EDX) analysis. Results revealed that the as-obtained SeNP/OCS powder exhibits high purity. The SeNP/OCS solution’s stability test results indicated that the SeNP/OCS solution stored at 4°C exhibits good stability for 60 days. The SeNP/OCS solution was unstable at ambient temperature, and SeNP/OCS exhibited agglomeration after about 15 days. SeNP/OCS products recovered the total white blood cells of γ-ray irradiated mice. The SeNP/OCS product, which was synthesised by a green approach, with high purity and efficient recuperation of white blood cells, can be used potentially as a functional supplement to assist cancer radiotherapy patients.http://dx.doi.org/10.1155/2021/6635022 |
| spellingShingle | Duy Ngoc Nguyen Phu Van Dang Quoc Anh Le Lan Thi Kim Nguyen Hien Quoc Nguyen Ngan Thi Thu Tran Ha Le Bao Tran Tuan Dinh Phan Ha Manh Bui Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation Journal of Chemistry |
| title | Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation |
| title_full | Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation |
| title_fullStr | Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation |
| title_full_unstemmed | Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation |
| title_short | Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation |
| title_sort | preparation and effect of selenium nanoparticles oligochitosan on the white blood cell recovery of mice exposed to gamma ray radiation |
| url | http://dx.doi.org/10.1155/2021/6635022 |
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