Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis
Recent studies have emphasized the impact of gut microbiota on skin health, but the reverse, how skin diseases affect gut homeostasis, has received less attention. Allergic contact dermatitis (ACD), a common skin disorder affecting one in four people worldwide, can be accompanied by intestinal distu...
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MDPI AG
2025-05-01
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| author | Eduardo Mendes Evelyn Roxana Perez Umana Daniel Di Pace Soares Penna Fernando Augusto de Oliveira Leandro Nascimento Lemos Willian Rodrigues Ribeiro Mateus Barbosa Casaro Mariana Lazarini Valéria Maia Oliveira Caroline Marcantonio Ferreira |
| author_facet | Eduardo Mendes Evelyn Roxana Perez Umana Daniel Di Pace Soares Penna Fernando Augusto de Oliveira Leandro Nascimento Lemos Willian Rodrigues Ribeiro Mateus Barbosa Casaro Mariana Lazarini Valéria Maia Oliveira Caroline Marcantonio Ferreira |
| author_sort | Eduardo Mendes |
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| description | Recent studies have emphasized the impact of gut microbiota on skin health, but the reverse, how skin diseases affect gut homeostasis, has received less attention. Allergic contact dermatitis (ACD), a common skin disorder affecting one in four people worldwide, can be accompanied by intestinal disturbances. To explore this, we used an experimental model of ACD to investigate the intestinal changes induced by the disease. Parameters assessed included intestinal microbiota, short-chain fatty acids (SCFAs), gene expression related to intestinal permeability, inflammatory cytokines, and mucus production. To evaluate potential therapeutic interventions, the probiotic <i>Bifidobacterium longum</i> strain BB536 was administered via gavage, starting 10 days before dermatitis induction and continuing until the last day of disease induction. ACD caused alterations in the composition of intestinal microbiota compared to naïve mice but did not affect SCFA production. The probiotic altered microbiota composition and increased acetate production in dermatitis-induced mice. ACD decreased the gene expression of <i>TjP1</i>, <i>ATHO1</i>, and <i>MUC2</i>, while probiotic treatment restored <i>TjP1</i> and <i>ATHO1</i> to normal levels. The cytokine IL-6 increased in the ACD group compared to naïve mice, whereas IL-10 decreased; probiotic treatment also restored these levels. Intestinal mucus production, affected by ACD, was partially restored by probiotic treatment. The findings suggest that probiotics could be a therapeutic strategy to prevent intestinal issues caused by skin diseases. |
| format | Article |
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| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Microorganisms |
| spelling | doaj-art-d02cac11f67e49d196a00816105723382025-08-20T03:47:58ZengMDPI AGMicroorganisms2076-26072025-05-01135108210.3390/microorganisms13051082Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact DermatitisEduardo Mendes0Evelyn Roxana Perez Umana1Daniel Di Pace Soares Penna2Fernando Augusto de Oliveira3Leandro Nascimento Lemos4Willian Rodrigues Ribeiro5Mateus Barbosa Casaro6Mariana Lazarini7Valéria Maia Oliveira8Caroline Marcantonio Ferreira9Institute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de São Paulo, Diadema 04021-001, BrazilInstitute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de São Paulo, Diadema 04021-001, BrazilDivision of Microbial Resources, Multidisciplinary Center for Chemical, Biological and Agricultural Research (CPQBA), State University of Campinas (UNICAMP), Paulínia 13148-218, BrazilCellular and Molecular Neurobiology Laboratory (LaNeC), Center of Mathematics, Computing and Cognition (CMCC), Federal University of ABC, São Bernardo do Campo 09280-560, BrazilIlum School of Science, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas 13083-100, BrazilInstitute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de São Paulo, Diadema 04021-001, BrazilInstitute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de São Paulo, Diadema 04021-001, BrazilInstitute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de São Paulo, Diadema 04021-001, BrazilDivision of Microbial Resources, Multidisciplinary Center for Chemical, Biological and Agricultural Research (CPQBA), State University of Campinas (UNICAMP), Paulínia 13148-218, BrazilInstitute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de São Paulo, Diadema 04021-001, BrazilRecent studies have emphasized the impact of gut microbiota on skin health, but the reverse, how skin diseases affect gut homeostasis, has received less attention. Allergic contact dermatitis (ACD), a common skin disorder affecting one in four people worldwide, can be accompanied by intestinal disturbances. To explore this, we used an experimental model of ACD to investigate the intestinal changes induced by the disease. Parameters assessed included intestinal microbiota, short-chain fatty acids (SCFAs), gene expression related to intestinal permeability, inflammatory cytokines, and mucus production. To evaluate potential therapeutic interventions, the probiotic <i>Bifidobacterium longum</i> strain BB536 was administered via gavage, starting 10 days before dermatitis induction and continuing until the last day of disease induction. ACD caused alterations in the composition of intestinal microbiota compared to naïve mice but did not affect SCFA production. The probiotic altered microbiota composition and increased acetate production in dermatitis-induced mice. ACD decreased the gene expression of <i>TjP1</i>, <i>ATHO1</i>, and <i>MUC2</i>, while probiotic treatment restored <i>TjP1</i> and <i>ATHO1</i> to normal levels. The cytokine IL-6 increased in the ACD group compared to naïve mice, whereas IL-10 decreased; probiotic treatment also restored these levels. Intestinal mucus production, affected by ACD, was partially restored by probiotic treatment. The findings suggest that probiotics could be a therapeutic strategy to prevent intestinal issues caused by skin diseases.https://www.mdpi.com/2076-2607/13/5/1082dermatitismicrobiomeallergyintestine |
| spellingShingle | Eduardo Mendes Evelyn Roxana Perez Umana Daniel Di Pace Soares Penna Fernando Augusto de Oliveira Leandro Nascimento Lemos Willian Rodrigues Ribeiro Mateus Barbosa Casaro Mariana Lazarini Valéria Maia Oliveira Caroline Marcantonio Ferreira Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis Microorganisms dermatitis microbiome allergy intestine |
| title | Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis |
| title_full | Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis |
| title_fullStr | Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis |
| title_full_unstemmed | Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis |
| title_short | Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis |
| title_sort | probiotic administration contributes to the improvement in intestinal dysregulation induced by allergic contact dermatitis |
| topic | dermatitis microbiome allergy intestine |
| url | https://www.mdpi.com/2076-2607/13/5/1082 |
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