Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.
Abstract A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1–11). Notably, the newly identified dibohemamines I–O (1–7) have not been previously reported. Their structures were elucidated...
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| Format: | Article |
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SpringerOpen
2025-01-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | https://doi.org/10.1007/s13659-024-00494-4 |
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| author | Dong-Yang Wang Ming-Xing Li Yan-Chao Xu Peng Fu Wei-Ming Zhu Li-Ping Wang |
| author_facet | Dong-Yang Wang Ming-Xing Li Yan-Chao Xu Peng Fu Wei-Ming Zhu Li-Ping Wang |
| author_sort | Dong-Yang Wang |
| collection | DOAJ |
| description | Abstract A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1–11). Notably, the newly identified dibohemamines I–O (1–7) have not been previously reported. Their structures were elucidated through detailed spectroscopic analysis, encompassing high-resolution electrospray ionization mass, nuclear magnetic resonance, infrared radiation, ultraviolet–visible, and electronic circular dichroism spectroscopy. Dibohemamine I (1) exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated, with the half-inhibitory concentration values of 3.24 ± 0.20 and 7.36 ± 0.41 μM, respectively. Graphical Abstract |
| format | Article |
| id | doaj-art-d02c53022a044c28b95ed1447ac80a22 |
| institution | OA Journals |
| issn | 2192-2195 2192-2209 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj-art-d02c53022a044c28b95ed1447ac80a222025-08-20T02:35:39ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092025-01-0115111010.1007/s13659-024-00494-4Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.Dong-Yang Wang0Ming-Xing Li1Yan-Chao Xu2Peng Fu3Wei-Ming Zhu4Li-Ping Wang5State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical UniversityState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical UniversityState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical UniversitySchool of Medicine and Pharmacy, Ocean University of ChinaState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical UniversityState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical UniversityAbstract A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1–11). Notably, the newly identified dibohemamines I–O (1–7) have not been previously reported. Their structures were elucidated through detailed spectroscopic analysis, encompassing high-resolution electrospray ionization mass, nuclear magnetic resonance, infrared radiation, ultraviolet–visible, and electronic circular dichroism spectroscopy. Dibohemamine I (1) exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated, with the half-inhibitory concentration values of 3.24 ± 0.20 and 7.36 ± 0.41 μM, respectively. Graphical Abstracthttps://doi.org/10.1007/s13659-024-00494-4Endophytic actinomyceteSecondary metaboliteDibohemamineCytotoxicity |
| spellingShingle | Dong-Yang Wang Ming-Xing Li Yan-Chao Xu Peng Fu Wei-Ming Zhu Li-Ping Wang Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb. Natural Products and Bioprospecting Endophytic actinomycete Secondary metabolite Dibohemamine Cytotoxicity |
| title | Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb. |
| title_full | Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb. |
| title_fullStr | Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb. |
| title_full_unstemmed | Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb. |
| title_short | Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb. |
| title_sort | dibohemamines i o from streptomyces sp gzwmjz 662 an endophytic actinomycete from the medicinal and edible plant houttuynia cordata thunb |
| topic | Endophytic actinomycete Secondary metabolite Dibohemamine Cytotoxicity |
| url | https://doi.org/10.1007/s13659-024-00494-4 |
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