The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members

The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members

Summary: Innate immunity relies on pattern recognition receptors (PRRs) to detect threats, including pathogens and damage-associated molecular patterns (DAMPs) from damaged cells. IFI16 behaves as a DAMP and activates Toll-like receptor 4 (TLR4)-mediated inflammation. Here, we identify the N-termina...

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Bibliographic Details
Main Authors: Andrea Iannucci, Davide Lacarbonara, Valeria Caneparo, Federica Castiglioni, Andrea Butticè, Stefano Raviola, Chiara Porta, Riccardo Miggiano, Ivan Zanoni, Marisa Gariglio, Marco De Andrea
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Molecular biology
Immune response
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225006741
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