Exploring Neuroprotection against Radiation-Induced Brain Injury: A Review of Key Compounds

Exploring Neuroprotection against Radiation-Induced Brain Injury: A Review of Key Compounds

Brain radiation is a crucial tool in neuro-oncology for enhancing local tumor control, but it can lead to mild-to-profound and progressive impairments in cognitive function. Radiation-induced brain injury is a significant adverse effect of radiotherapy for cranioencephalic tumors, primarily caused b...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lucas González-Johnson, Ariel Fariña, Gonzalo Farías, Gustavo Zomosa, Víctor Pinilla-González, Catalina Rojas-Solé
Format:	Article
Language:	English
Published:	MDPI AG 2024-10-01
Series:	NeuroSci
Subjects:	cognitive impairment radiation-induced brain injury free radicals translational medicine whole brain radiation therapy ascorbate
Online Access:	https://www.mdpi.com/2673-4087/5/4/34
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A retrospective propensity-matched study comparing whole-brain radiotherapy with simultaneous integrated boost to whole-brain radiotherapy alone for brain metastases
by: Zheqing Liu, et al.
Published: (2025-07-01)

Management of solitary and multiple brain metastases from breast cancer
by: Addison Willett, et al.
Published: (2015-01-01)

Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors
by: Chris Staudinger, et al.
Published: (2024-11-01)

Effect of Whole‐Brain Radiotherapy Dose on the Occurrence of Otitis Media and Mastoiditis in Patients With Lung Cancer With Brain Metastasis
by: Xudong Zhang, et al.
Published: (2025-06-01)

A Diagnostic Conundrum: Cerebral Radiation Necrosis Masquerading as Tumor in the Contralateral Hemisphere
by: Tanshi Daljit, et al.

Parotid gland as an organ at risk in whole-brain radiation therapy: A retrospective comparison of 3D-CRT and IMRT techniques from a tertiary cancer center
by: RA Sunil, et al.
Published: (2025-04-01)

Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment
by: Keisuke Kokubun, et al.
Published: (2025-03-01)

The Pathogenesis and Prevention Strategies of Radiation-Induced Brain Injury
by: Wang Y, et al.
Published: (2025-07-01)

Radiation-Induced Brain Injury with Special Reference to Astrocytes as a Therapeutic Target
by: Caiping Wang, et al.
Published: (2025-03-01)

Alpha/beta values in pediatric medulloblastoma: implications for tailored approaches in radiation oncology
by: Danny Jazmati, et al.
Published: (2025-01-01)

Current neuroimaging modalities in differential diagnosis of radiation-induced brain injury in patients with brain tumors
by: T. Yu. Skvortsova, et al.
Published: (2011-08-01)

MODERN IDEAS ABOUT THE COMBINATION OF RADIATION THERAPY WITH ANTIANGIOGENIC DRUGS IN THE TREATMENT OF PATIENTS WITH BRAIN METASTASES
by: O. I. Kit, et al.
Published: (2020-03-01)

Brain MRI and regional vulnerabilities to radiation necrosis: investigating the impact of stereotactic radiotherapy in brain metastases treatment
by: Carlo A. Mallio, et al.
Published: (2025-04-01)

Dosimetric Analysis with Intensity-modulated Radiation Therapy for Central Nervous System Irradiation in Patients with Brain Cancer Compared with Threedimensional Conformal Radiation Therapy Treatment
by: Noor S. Omar, et al.
Published: (2019-12-01)

Radiation-Induced Brain Injury: Mechanistic Insights and the Promise of Gut–Brain Axis Therapies
by: Mengting Li, et al.
Published: (2024-12-01)

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
by: Peng Wang, et al.
Published: (2025-08-01)

Neuroprotective effects of bone marrow mesenchymal stem cells combined with mannitol on radiation-induced brain injury by regulating autophagy via the PI3K/AKT/mTOR signaling pathway
by: Shichao Pan, et al.
Published: (2025-05-01)

Radiation from frequent whole-body CT scans induces systemic immunosuppression and immune activation of tumor tissue
by: Jigang Dong, et al.
Published: (2025-04-01)

Advances in Radiation/Photon therapy technology for the treatment of brain metastases
by: Hui Wang, et al.
Published: (2025-07-01)

LOCKED-IN SYNDROME DUE TO MULTIPLE BRAIN STEM INFARCTIONS AND FOCI OF DEMYELINATION AFTER RADIATION THERAPY OF PITUITARY ADENOMA WITH ACROMEGALY
by: L. G. Zaslavskii, et al.
Published: (2018-12-01)

Radioprotective Agents Based on Complex Compounds of 3d Metals with Vitamins and Aminoacids
by: N. M. Kebets, et al.
Published: (2025-02-01)

The Effect of Concomitant Immunotherapy and Stereotactic Radiotherapy, and of Location on Survival in Patients With Brain Metastases From Melanoma
by: Chiel B. Nijboer, et al.
Published: (2025-06-01)

Cranial radiation disrupts dopaminergic signaling and connectivity in the mammalian brain
by: Die Zhang, et al.
Published: (2025-03-01)

Protective effects of AER-271 in acute-phase radiation-induced brain injury in rats: reduction of brain edema, inflammation, apoptosis and maintenance of blood-brain barrier integrity
by: Yaozu Xiong, et al.
Published: (2025-05-01)

Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation
by: Njenga R. Kamau, et al.
Published: (2025-04-01)

Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure
by: Lina Al-jameel, et al.
Published: (2025-04-01)

Interstitial space between cells in the left and right lobes of rat brains exposed to 900, 1800 and 2100 MHz radiofrequency radiation
by: Suleyman Dasdag, et al.
Published: (2023-03-01)

Radiation dermatitis in the hairless mouse model mimics human radiation dermatitis
by: Jessica Lawrence, et al.
Published: (2024-10-01)

RESULTS OF RADIOSURGICAL AND DRUG TREATMENT OF PATIENTS WITH BRAIN METASTASES
by: S. M. Banov, et al.
Published: (2017-11-01)

Brain Radiotherapy and Cognition
by: J Gordon Millichap
Published: (1992-12-01)

Dynamics of free-radical processes in the animals after protracted influence of exogenous nitric oxide and ionizing radiation
by: L. I. Makovetska, et al.
Published: (2012-12-01)

Optimizing Radiation Dose and Image Quality in Stroke CT Protocols: Proposed Diagnostic Reference Levels for Multiphase CT Angiography and Perfusion Imaging
by: Robert Forbrig, et al.
Published: (2024-12-01)

Radiation-induced intestinal injury
by: Asfold I. Parfenov, et al.
Published: (2025-01-01)

Radiation-induced changes of reactive astrocyte distribution in mice as a late response to partial-brain proton irradiation
by: Robin Hegering, et al.
Published: (2025-07-01)

High incidence of radiation-induced brain necrosis in the periventricular deep white matter: stereotactic radiotherapy for brain metastases using volumetric modulated arc therapy
by: Takayuki Ohguri, et al.
Published: (2025-01-01)

Proton therapy in pediatric neuro-oncology. Potential advantages and the relationship between cost and results
by: O. S. Regentova, et al.
Published: (2024-05-01)

Genome-wide transcriptomic response of whole blood to radiation
by: Ahmed Salah, et al.
Published: (2025-06-01)

Study of the Radiosensitizing Action of Lithium Ascorbate Under Neutron and Photon Irradiation of Tumor Cells
by: M. S. Tretyakova, et al.
Published: (2023-05-01)

Radiation effect from a mobile phone on brain tumor growth
by: A. V. Babalyan
Published: (2015-03-01)

Whole Transcriptome-Based ceRNA Regulatory Network Analysis of Radiation-Induced Esophageal Epithelial Cell Injury
by: Lin H, et al.
Published: (2025-04-01)