Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease.

Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease.

Sandhoff disease (SD) is a glycosphingolipid storage disease that arises from mutations in the Hexb gene and the resultant deficiency in β-hexosaminidase activity. This deficiency results in aberrant lysosomal accumulation of the ganglioside GM2 and related glycolipids, and progressive deterioration...

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Bibliographic Details
Main Authors: Yasuhiro Ogawa, Makoto Tanaka, Miho Tanabe, Toshihiro Suzuki, Tadayasu Togawa, Tomoko Fukushige, Takuro Kanekura, Hitoshi Sakuraba, Kazuhiko Oishi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055856&type=printable
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