Brain-Derived Neurotrophic Factor in Chronic Periodontitis
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts. Although a role for BDNF in periodontal regeneration has...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/373765 |
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| author | Jôice Dias Corrêa Daniele Sirineu Pereira Mila Fernandes Moreira Madeira Celso Martins Queiroz-Junior Danielle Glória Souza Mauro Martins Teixeira José Eustáquio Costa Antônio Lúcio Teixeira Tarcília Aparecida da Silva |
| author_facet | Jôice Dias Corrêa Daniele Sirineu Pereira Mila Fernandes Moreira Madeira Celso Martins Queiroz-Junior Danielle Glória Souza Mauro Martins Teixeira José Eustáquio Costa Antônio Lúcio Teixeira Tarcília Aparecida da Silva |
| author_sort | Jôice Dias Corrêa |
| collection | DOAJ |
| description | Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts. Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied. The aim of this study was to analyze the BDNF levels in periodontal tissues of patients with chronic periodontitis (CP) and periodontally healthy controls (HC). All subjects were genotyped for the rs4923463 and rs6265 BDNF polymorphisms. Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and microscopic analysis from 28 CP patients and 29 HC subjects. BDNF levels were increased in CP patients compared to HC subjects. A negative correlation was observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium. No differences in frequencies of BDNF genotypes between CP and HC subjects were observed. However, BDNF genotype GG was associated with increased levels of BDNF, TNF-α, and CXCL10 in CP patients. In conclusion, BDNF seems to be associated with periodontal disease process, but the specific role of BDNF still needs to be clarified. |
| format | Article |
| id | doaj-art-d022868969124682ae2392eeb740db8a |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d022868969124682ae2392eeb740db8a2025-08-20T03:19:45ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/373765373765Brain-Derived Neurotrophic Factor in Chronic PeriodontitisJôice Dias Corrêa0Daniele Sirineu Pereira1Mila Fernandes Moreira Madeira2Celso Martins Queiroz-Junior3Danielle Glória Souza4Mauro Martins Teixeira5José Eustáquio Costa6Antônio Lúcio Teixeira7Tarcília Aparecida da Silva8Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Physical Therapy, School of Physical Education, Physical Therapy and Occupational Therapy, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Professor Alfredo Balena Avenue 110, 30130-100 Belo Horizonte, MG, BrazilDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, BrazilBrain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts. Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied. The aim of this study was to analyze the BDNF levels in periodontal tissues of patients with chronic periodontitis (CP) and periodontally healthy controls (HC). All subjects were genotyped for the rs4923463 and rs6265 BDNF polymorphisms. Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and microscopic analysis from 28 CP patients and 29 HC subjects. BDNF levels were increased in CP patients compared to HC subjects. A negative correlation was observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium. No differences in frequencies of BDNF genotypes between CP and HC subjects were observed. However, BDNF genotype GG was associated with increased levels of BDNF, TNF-α, and CXCL10 in CP patients. In conclusion, BDNF seems to be associated with periodontal disease process, but the specific role of BDNF still needs to be clarified.http://dx.doi.org/10.1155/2014/373765 |
| spellingShingle | Jôice Dias Corrêa Daniele Sirineu Pereira Mila Fernandes Moreira Madeira Celso Martins Queiroz-Junior Danielle Glória Souza Mauro Martins Teixeira José Eustáquio Costa Antônio Lúcio Teixeira Tarcília Aparecida da Silva Brain-Derived Neurotrophic Factor in Chronic Periodontitis Mediators of Inflammation |
| title | Brain-Derived Neurotrophic Factor in Chronic Periodontitis |
| title_full | Brain-Derived Neurotrophic Factor in Chronic Periodontitis |
| title_fullStr | Brain-Derived Neurotrophic Factor in Chronic Periodontitis |
| title_full_unstemmed | Brain-Derived Neurotrophic Factor in Chronic Periodontitis |
| title_short | Brain-Derived Neurotrophic Factor in Chronic Periodontitis |
| title_sort | brain derived neurotrophic factor in chronic periodontitis |
| url | http://dx.doi.org/10.1155/2014/373765 |
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