Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease
BackgroundActigraphy is widely used to detect a decline in physical activity in aged individuals with cerebral small vessel disease (cSVD). Disturbed fractal physical activity has been reported in aged adults with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and other neuropsychiatric...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1569582/full |
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| author | Hóngyi Zhào Hóngyi Zhào Wei Wei Fang Lv Jie Shen Yonghua Huang |
| author_facet | Hóngyi Zhào Hóngyi Zhào Wei Wei Fang Lv Jie Shen Yonghua Huang |
| author_sort | Hóngyi Zhào |
| collection | DOAJ |
| description | BackgroundActigraphy is widely used to detect a decline in physical activity in aged individuals with cerebral small vessel disease (cSVD). Disturbed fractal physical activity has been reported in aged adults with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and other neuropsychiatric disorders.ObjectivesTo analyze the fractal physical activity pattern in elderly patients with cSVD.MethodsFrom May 2021 to August 2023, 55 patients with cSVD aged 60–80 years admitted to the seventh medical center of PLA General Hospital were included. The presence of lacunes, white matter hyperintensities, cerebral microbleeds, and perivascular spaces on magnetic resonance images (MRI) were rated independently. Furthermore, these MRI markers were summed in a score of 0–4, representing all cSVD features combined. Detrended fluctuation analysis (DFA) was used to evaluate the fractal physical activity fluctuations at multiple time scales. The relationship between the fractal physical activity pattern and physical activity and sleep quality was analyzed with partial Pearson correlation analysis.ResultsIndividuals with a low severity cSVD burden showed a significant tendency toward a random fractal pattern relative to those with a higher severity cSVD burden. Similar results were obtained when comparing the lacune positive and negative groups. In aged adults with cSVD, fractal disturbance was associated with an average level of physical activity and not sleep quality.ConclusionThese findings demonstrate the presence of obvious fractal physical activity complexity in aged adults with cSVD. |
| format | Article |
| id | doaj-art-d021d62a1f944fe8920b35779bab7cbb |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-d021d62a1f944fe8920b35779bab7cbb2025-08-20T02:19:57ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-04-011710.3389/fnagi.2025.15695821569582Detecting the fractal physical activity pattern in aged adults with cerebral small vessel diseaseHóngyi Zhào0Hóngyi Zhào1Wei Wei2Fang Lv3Jie Shen4Yonghua Huang5Department of Neurology, Seventh Medical Centre of PLA General Hospital, Beijing, ChinaDepartment of Psychiatry, No 984 Hospital of PLA, Beijing, ChinaDepartment of Neurology, Seventh Medical Centre of PLA General Hospital, Beijing, ChinaDepartment of Gerontology, No 984 Hospital of PLA, Beijing, ChinaDepartment of Neurology, Seventh Medical Centre of PLA General Hospital, Beijing, ChinaDepartment of Neurology, Seventh Medical Centre of PLA General Hospital, Beijing, ChinaBackgroundActigraphy is widely used to detect a decline in physical activity in aged individuals with cerebral small vessel disease (cSVD). Disturbed fractal physical activity has been reported in aged adults with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and other neuropsychiatric disorders.ObjectivesTo analyze the fractal physical activity pattern in elderly patients with cSVD.MethodsFrom May 2021 to August 2023, 55 patients with cSVD aged 60–80 years admitted to the seventh medical center of PLA General Hospital were included. The presence of lacunes, white matter hyperintensities, cerebral microbleeds, and perivascular spaces on magnetic resonance images (MRI) were rated independently. Furthermore, these MRI markers were summed in a score of 0–4, representing all cSVD features combined. Detrended fluctuation analysis (DFA) was used to evaluate the fractal physical activity fluctuations at multiple time scales. The relationship between the fractal physical activity pattern and physical activity and sleep quality was analyzed with partial Pearson correlation analysis.ResultsIndividuals with a low severity cSVD burden showed a significant tendency toward a random fractal pattern relative to those with a higher severity cSVD burden. Similar results were obtained when comparing the lacune positive and negative groups. In aged adults with cSVD, fractal disturbance was associated with an average level of physical activity and not sleep quality.ConclusionThese findings demonstrate the presence of obvious fractal physical activity complexity in aged adults with cSVD.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1569582/fullactigraphyagingsmall vessel diseaseneurodegenerative diseasewearable |
| spellingShingle | Hóngyi Zhào Hóngyi Zhào Wei Wei Fang Lv Jie Shen Yonghua Huang Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease Frontiers in Aging Neuroscience actigraphy aging small vessel disease neurodegenerative disease wearable |
| title | Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease |
| title_full | Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease |
| title_fullStr | Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease |
| title_full_unstemmed | Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease |
| title_short | Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease |
| title_sort | detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease |
| topic | actigraphy aging small vessel disease neurodegenerative disease wearable |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1569582/full |
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