Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives
The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6143129 |
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| _version_ | 1850172578725888000 |
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| author | Luis E. León Sweta Rani Mauricio Fernandez Martín Larico Sebastián D. Calligaris |
| author_facet | Luis E. León Sweta Rani Mauricio Fernandez Martín Larico Sebastián D. Calligaris |
| author_sort | Luis E. León |
| collection | DOAJ |
| description | The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases. In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation. Currently, biochemical and imaging diagnostic methods are unable to detect subclinical manifestation of the disease (prior to diastolic dysfunction). In this review, we elaborately discuss the current scientific evidences to propose circulating microRNAs as promising biomarkers for early detection of diabetic cardiomyopathy and, then, to identify patients at high risk of diabetic cardiomyopathy development. Moreover, here we summarise the research strategies to identify miRNAs as potential biomarkers, present limitations, challenges, and future perspectives. |
| format | Article |
| id | doaj-art-d0205cdc89a64e558d28ba04decc0e39 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d0205cdc89a64e558d28ba04decc0e392025-08-20T02:20:03ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/61431296143129Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and PerspectivesLuis E. León0Sweta Rani1Mauricio Fernandez2Martín Larico3Sebastián D. Calligaris4Centro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, 7710162 Santiago, ChileRegenerative Medicine Institute (REMEDI), National University of Ireland, Galway, IrelandClínica Alemana, 7650568 Santiago, ChileClínica Alemana, 7650568 Santiago, ChileCentro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, 7710162 Santiago, ChileThe prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases. In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation. Currently, biochemical and imaging diagnostic methods are unable to detect subclinical manifestation of the disease (prior to diastolic dysfunction). In this review, we elaborately discuss the current scientific evidences to propose circulating microRNAs as promising biomarkers for early detection of diabetic cardiomyopathy and, then, to identify patients at high risk of diabetic cardiomyopathy development. Moreover, here we summarise the research strategies to identify miRNAs as potential biomarkers, present limitations, challenges, and future perspectives.http://dx.doi.org/10.1155/2016/6143129 |
| spellingShingle | Luis E. León Sweta Rani Mauricio Fernandez Martín Larico Sebastián D. Calligaris Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives Journal of Diabetes Research |
| title | Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives |
| title_full | Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives |
| title_fullStr | Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives |
| title_full_unstemmed | Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives |
| title_short | Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives |
| title_sort | subclinical detection of diabetic cardiomyopathy with micrornas challenges and perspectives |
| url | http://dx.doi.org/10.1155/2016/6143129 |
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