Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan
Objective: Cefiderocol, a siderophore cephalosporin, has shown promise against carbapenem-resistant strains such as Pseudomonas aeruginosa and Stenotrophomonas maltophilia species complex. Despite its recent approval in Japan, susceptibility data remain limited. Therefore, this study evaluated the c...
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Elsevier
2025-09-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716525001584 |
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| author | Wataru Aoki Yoshifumi Uwamino Nagi Niida Hiroaki Kubota Yuka Kamoshita Rika Inose Mika Nagata Osamu Ishihara Shunsuke Uno Ayumi Yoshifuji Ho Namkoong Naoki Hasegawa Hiromichi Matsushita |
| author_facet | Wataru Aoki Yoshifumi Uwamino Nagi Niida Hiroaki Kubota Yuka Kamoshita Rika Inose Mika Nagata Osamu Ishihara Shunsuke Uno Ayumi Yoshifuji Ho Namkoong Naoki Hasegawa Hiromichi Matsushita |
| author_sort | Wataru Aoki |
| collection | DOAJ |
| description | Objective: Cefiderocol, a siderophore cephalosporin, has shown promise against carbapenem-resistant strains such as Pseudomonas aeruginosa and Stenotrophomonas maltophilia species complex. Despite its recent approval in Japan, susceptibility data remain limited. Therefore, this study evaluated the cefiderocol susceptibility of carbapenem-resistant P. aeruginosa and S. maltophilia species complex strains isolated from blood cultures to determine whether cefiderocol can be used as an empirical treatment option. Methods: Carbapenem-resistant P. aeruginosa and S. maltophilia species complex strains isolated from blood cultures at a university hospital in Japan were included. Minimum inhibitory concentrations (MICs) and inhibition zone diameters were assessed using broth microdilution and disk diffusion methods, respectively. Whole-genome sequencing was conducted to elucidate the genetic backgrounds of the clinical isolates. Results: The MIC50 and MIC90 values for cefiderocol in 65 carbapenem-resistant P. aeruginosa strains were 0.12 and 0.25 µg/mL, and 0.06 and 0.25 µg/mL for 51 S. maltophilia species complex strains, respectively. One S. maltophilia species complex strain exhibited non-susceptibility, with a MIC of 2 µg/mL in broth microdilution, while disk diffusion methods demonstrated susceptibility. A significant negative correlation was observed between MIC values and inhibition zone diameters. Whole-genome sequencing revealed that a limited number of P. aeruginosa strains possessed carbapenemase genes. Conclusions: The findings of this study support the efficacy of cefiderocol against carbapenem-resistant P. aeruginosa and S. maltophilia species complex, suggesting its potential as an empirical treatment option for bloodstream infection patients in Japan. Continued surveillance is advised to monitor resistance trends with increased cefiderocol use. |
| format | Article |
| id | doaj-art-d018bf7626674133a69a70c1c55bbfd6 |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-d018bf7626674133a69a70c1c55bbfd62025-08-20T03:56:42ZengElsevierJournal of Global Antimicrobial Resistance2213-71652025-09-014425125510.1016/j.jgar.2025.07.004Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, JapanWataru Aoki0Yoshifumi Uwamino1Nagi Niida2Hiroaki Kubota3Yuka Kamoshita4Rika Inose5Mika Nagata6Osamu Ishihara7Shunsuke Uno8Ayumi Yoshifuji9Ho Namkoong10Naoki Hasegawa11Hiromichi Matsushita12Clinical Laboratory, Keio University Hospital, Tokyo, JapanDepartment of Laboratory Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan; Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan; Corresponding author. Mailing address: Department of Laboratory Medicine, Keio University School of Medicine. 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.Clinical Laboratory, Keio University Hospital, Tokyo, JapanDepartment of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, JapanDepartment of Laboratory Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, JapanClinical Laboratory, Keio University Hospital, Tokyo, JapanClinical Laboratory, Keio University Hospital, Tokyo, JapanClinical Laboratory, Keio University Hospital, Tokyo, JapanDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, JapanDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, JapanDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, JapanDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, JapanDepartment of Laboratory Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, JapanObjective: Cefiderocol, a siderophore cephalosporin, has shown promise against carbapenem-resistant strains such as Pseudomonas aeruginosa and Stenotrophomonas maltophilia species complex. Despite its recent approval in Japan, susceptibility data remain limited. Therefore, this study evaluated the cefiderocol susceptibility of carbapenem-resistant P. aeruginosa and S. maltophilia species complex strains isolated from blood cultures to determine whether cefiderocol can be used as an empirical treatment option. Methods: Carbapenem-resistant P. aeruginosa and S. maltophilia species complex strains isolated from blood cultures at a university hospital in Japan were included. Minimum inhibitory concentrations (MICs) and inhibition zone diameters were assessed using broth microdilution and disk diffusion methods, respectively. Whole-genome sequencing was conducted to elucidate the genetic backgrounds of the clinical isolates. Results: The MIC50 and MIC90 values for cefiderocol in 65 carbapenem-resistant P. aeruginosa strains were 0.12 and 0.25 µg/mL, and 0.06 and 0.25 µg/mL for 51 S. maltophilia species complex strains, respectively. One S. maltophilia species complex strain exhibited non-susceptibility, with a MIC of 2 µg/mL in broth microdilution, while disk diffusion methods demonstrated susceptibility. A significant negative correlation was observed between MIC values and inhibition zone diameters. Whole-genome sequencing revealed that a limited number of P. aeruginosa strains possessed carbapenemase genes. Conclusions: The findings of this study support the efficacy of cefiderocol against carbapenem-resistant P. aeruginosa and S. maltophilia species complex, suggesting its potential as an empirical treatment option for bloodstream infection patients in Japan. Continued surveillance is advised to monitor resistance trends with increased cefiderocol use.http://www.sciencedirect.com/science/article/pii/S2213716525001584CefiderocolCarbapenem resistanceStenotrophomonas maltophiliaPseudomonas aeruginosaBloodstream infectionSusceptibility |
| spellingShingle | Wataru Aoki Yoshifumi Uwamino Nagi Niida Hiroaki Kubota Yuka Kamoshita Rika Inose Mika Nagata Osamu Ishihara Shunsuke Uno Ayumi Yoshifuji Ho Namkoong Naoki Hasegawa Hiromichi Matsushita Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan Journal of Global Antimicrobial Resistance Cefiderocol Carbapenem resistance Stenotrophomonas maltophilia Pseudomonas aeruginosa Bloodstream infection Susceptibility |
| title | Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan |
| title_full | Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan |
| title_fullStr | Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan |
| title_full_unstemmed | Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan |
| title_short | Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan |
| title_sort | cefiderocol susceptibility of stenotrophomonas maltophilia species complex and carbapenem resistant pseudomonas aeruginosa isolates from blood cultures at a university hospital in tokyo japan |
| topic | Cefiderocol Carbapenem resistance Stenotrophomonas maltophilia Pseudomonas aeruginosa Bloodstream infection Susceptibility |
| url | http://www.sciencedirect.com/science/article/pii/S2213716525001584 |
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