Qualitative study exploring reintegration of clinical trial participants with HIV to public health services in Johannesburg, South Africa
Objective People living with HIV (PLHIV) are often recruited from primary healthcare clinics (PHC) into clinical trials. On trial completion, they are transferred back to the facility for continued care and support in managing their condition, potentially leading to better health outcomes. Because t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-11-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/11/e084947.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850136429895614464 |
|---|---|
| author | Samanta Tresha Lalla-Edward Kelechi Elizabeth Oladimeji Sibongiseni Thandazani Nxumalo Bernice Harris Lizeka Napoles |
| author_facet | Samanta Tresha Lalla-Edward Kelechi Elizabeth Oladimeji Sibongiseni Thandazani Nxumalo Bernice Harris Lizeka Napoles |
| author_sort | Samanta Tresha Lalla-Edward |
| collection | DOAJ |
| description | Objective People living with HIV (PLHIV) are often recruited from primary healthcare clinics (PHC) into clinical trials. On trial completion, they are transferred back to the facility for continued care and support in managing their condition, potentially leading to better health outcomes. Because transferring PLHIV back to PHCs post-clinical trials may result in decreased access to specialised care or resources that were available during the trial, this study explored insights into challenges faced during reintegration from clinical trial settings into PHCs and antiretroviral therapy (ART) adherence post-clinical trials.Design This cross-sectional study was conducted using a qualitative research approach. Participants were recruited using purposive sampling.Setting The study was conducted at the Ezintsha Research Centre in Johannesburg, South Africa, between November 2022 and February 2023.Participants The study population consisted of PLHIV who had participated in two clinical trials (DORA and ADVANCE) at the Ezintsha Research Centre in Johannesburg, South Africa.Methods Using a semistructured guide, 12 in-depth interviews were conducted with PLHIV until data saturation was reached. Data were then transcribed verbatim and analysed thematically with MAXQDA software.Results The majority (n=8, 67%) of participants were female, and the average age of all participants was 40 (SD 7.2) years. Two main themes emerged: reintegration from clinical trials to public healthcare and barriers to ART adherence. These themes were further separated into seven subthemes, namely, negative attitude of healthcare workers, poor healthcare service delivery, poor communication to patients, waiting time at healthcare facilities, lack of privacy and confidentiality, mistakes in ART dispensing and bad reception at facilities post-clinical trials.Conclusion Clinical trial sites should cultivate better stakeholder engagement with PHCs to facilitate a smoother transition of research participants, especially PLHIV, back into public healthcare for continued care. |
| format | Article |
| id | doaj-art-d0111217bf464be18efcb26e52b1fbba |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-d0111217bf464be18efcb26e52b1fbba2025-08-20T02:31:08ZengBMJ Publishing GroupBMJ Open2044-60552024-11-01141110.1136/bmjopen-2024-084947Qualitative study exploring reintegration of clinical trial participants with HIV to public health services in Johannesburg, South AfricaSamanta Tresha Lalla-Edward0Kelechi Elizabeth Oladimeji1Sibongiseni Thandazani Nxumalo2Bernice Harris3Lizeka Napoles42 Ezintsha, A Division of Wits Health Consortium, University of the Witwatersrand Faculty of Health Sciences, Johannesburg, Gauteng, South Africa2 Ezintsha, A Division of Wits Health Consortium, University of the Witwatersrand Faculty of Health Sciences, Johannesburg, Gauteng, South Africa1 School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa1 School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa1 School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria, South AfricaObjective People living with HIV (PLHIV) are often recruited from primary healthcare clinics (PHC) into clinical trials. On trial completion, they are transferred back to the facility for continued care and support in managing their condition, potentially leading to better health outcomes. Because transferring PLHIV back to PHCs post-clinical trials may result in decreased access to specialised care or resources that were available during the trial, this study explored insights into challenges faced during reintegration from clinical trial settings into PHCs and antiretroviral therapy (ART) adherence post-clinical trials.Design This cross-sectional study was conducted using a qualitative research approach. Participants were recruited using purposive sampling.Setting The study was conducted at the Ezintsha Research Centre in Johannesburg, South Africa, between November 2022 and February 2023.Participants The study population consisted of PLHIV who had participated in two clinical trials (DORA and ADVANCE) at the Ezintsha Research Centre in Johannesburg, South Africa.Methods Using a semistructured guide, 12 in-depth interviews were conducted with PLHIV until data saturation was reached. Data were then transcribed verbatim and analysed thematically with MAXQDA software.Results The majority (n=8, 67%) of participants were female, and the average age of all participants was 40 (SD 7.2) years. Two main themes emerged: reintegration from clinical trials to public healthcare and barriers to ART adherence. These themes were further separated into seven subthemes, namely, negative attitude of healthcare workers, poor healthcare service delivery, poor communication to patients, waiting time at healthcare facilities, lack of privacy and confidentiality, mistakes in ART dispensing and bad reception at facilities post-clinical trials.Conclusion Clinical trial sites should cultivate better stakeholder engagement with PHCs to facilitate a smoother transition of research participants, especially PLHIV, back into public healthcare for continued care.https://bmjopen.bmj.com/content/14/11/e084947.full |
| spellingShingle | Samanta Tresha Lalla-Edward Kelechi Elizabeth Oladimeji Sibongiseni Thandazani Nxumalo Bernice Harris Lizeka Napoles Qualitative study exploring reintegration of clinical trial participants with HIV to public health services in Johannesburg, South Africa BMJ Open |
| title | Qualitative study exploring reintegration of clinical trial participants with HIV to public health services in Johannesburg, South Africa |
| title_full | Qualitative study exploring reintegration of clinical trial participants with HIV to public health services in Johannesburg, South Africa |
| title_fullStr | Qualitative study exploring reintegration of clinical trial participants with HIV to public health services in Johannesburg, South Africa |
| title_full_unstemmed | Qualitative study exploring reintegration of clinical trial participants with HIV to public health services in Johannesburg, South Africa |
| title_short | Qualitative study exploring reintegration of clinical trial participants with HIV to public health services in Johannesburg, South Africa |
| title_sort | qualitative study exploring reintegration of clinical trial participants with hiv to public health services in johannesburg south africa |
| url | https://bmjopen.bmj.com/content/14/11/e084947.full |
| work_keys_str_mv | AT samantatreshalallaedward qualitativestudyexploringreintegrationofclinicaltrialparticipantswithhivtopublichealthservicesinjohannesburgsouthafrica AT kelechielizabetholadimeji qualitativestudyexploringreintegrationofclinicaltrialparticipantswithhivtopublichealthservicesinjohannesburgsouthafrica AT sibongisenithandazaninxumalo qualitativestudyexploringreintegrationofclinicaltrialparticipantswithhivtopublichealthservicesinjohannesburgsouthafrica AT berniceharris qualitativestudyexploringreintegrationofclinicaltrialparticipantswithhivtopublichealthservicesinjohannesburgsouthafrica AT lizekanapoles qualitativestudyexploringreintegrationofclinicaltrialparticipantswithhivtopublichealthservicesinjohannesburgsouthafrica |