Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders
Abstract Background Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive stenosis or occlusion of the intracranial arteries, accompanied by the formation of fragile collateral vessels, ultimately leading to ischemic or hemorrhagic strokes. Immune dysregulation, p...
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BMC
2025-06-01
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| Series: | Journal of Neuroinflammation |
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| Online Access: | https://doi.org/10.1186/s12974-025-03479-3 |
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| author | Chenglong Liu Junsheng Li Siqi Mou Yuheng Pang Liujia Chan Qiheng He Wei Liu Zhikang Zhao Bojian Zhang Zhiyao Zheng Wei Sun Xiangjun Shi Qian Zhang Rong Wang Yan Zhang Wenjing Wang Dong Zhang Peicong Ge |
| author_facet | Chenglong Liu Junsheng Li Siqi Mou Yuheng Pang Liujia Chan Qiheng He Wei Liu Zhikang Zhao Bojian Zhang Zhiyao Zheng Wei Sun Xiangjun Shi Qian Zhang Rong Wang Yan Zhang Wenjing Wang Dong Zhang Peicong Ge |
| author_sort | Chenglong Liu |
| collection | DOAJ |
| description | Abstract Background Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive stenosis or occlusion of the intracranial arteries, accompanied by the formation of fragile collateral vessels, ultimately leading to ischemic or hemorrhagic strokes. Immune dysregulation, particularly involving T cell abnormalities and mitochondrial dysfunction, plays a critical role in the pathogenesis of MMD; however, their precise relationship remains unclear. Methods Peripheral blood mononuclear cells (PBMCs) from patients with MMD and healthy controls were analyzed using mass cytometry (CyTOF) and transcriptomic profiling. Additionally, clinical characteristics and neuroimaging data were collected to perform integrated correlation analyses with immune profiling data. Results Patients with MMD exhibited aberrant T cell activation and altered subset distribution, accompanied by mitochondrial dysfunction and impaired oxidative phosphorylation capacity. Increased oxidative stress and endoplasmic reticulum stress were observed in T cells, along with disease-specific downregulation of immune checkpoint molecules, including PD-1 and ICOS. Conclusions This study highlights the critical involvement of immune activation and mitochondrial dysfunction in the pathophysiology of MMD, providing novel insights into disease mechanisms and identifying immunometabolic pathways as potential targets for therapeutic intervention. |
| format | Article |
| id | doaj-art-d00a6bfca7b443bb8a8c29e457d8d3fc |
| institution | OA Journals |
| issn | 1742-2094 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj-art-d00a6bfca7b443bb8a8c29e457d8d3fc2025-08-20T02:30:42ZengBMCJournal of Neuroinflammation1742-20942025-06-0122112010.1186/s12974-025-03479-3Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disordersChenglong Liu0Junsheng Li1Siqi Mou2Yuheng Pang3Liujia Chan4Qiheng He5Wei Liu6Zhikang Zhao7Bojian Zhang8Zhiyao Zheng9Wei Sun10Xiangjun Shi11Qian Zhang12Rong Wang13Yan Zhang14Wenjing Wang15Dong Zhang16Peicong Ge17Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityBeijing YouAn Hospital, Beijing Institute of Hepatology, Capital Medical UniversityDepartment of Medicinal Chemistry, College of Pharmaceutical Sciences, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityChina National Clinical Research Center for Neurological DiseasesDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityBeijing YouAn Hospital, Beijing Institute of Hepatology, Capital Medical UniversityDepartment of Neurosurgery, Beijing Hospital, National Center of GerontologyDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive stenosis or occlusion of the intracranial arteries, accompanied by the formation of fragile collateral vessels, ultimately leading to ischemic or hemorrhagic strokes. Immune dysregulation, particularly involving T cell abnormalities and mitochondrial dysfunction, plays a critical role in the pathogenesis of MMD; however, their precise relationship remains unclear. Methods Peripheral blood mononuclear cells (PBMCs) from patients with MMD and healthy controls were analyzed using mass cytometry (CyTOF) and transcriptomic profiling. Additionally, clinical characteristics and neuroimaging data were collected to perform integrated correlation analyses with immune profiling data. Results Patients with MMD exhibited aberrant T cell activation and altered subset distribution, accompanied by mitochondrial dysfunction and impaired oxidative phosphorylation capacity. Increased oxidative stress and endoplasmic reticulum stress were observed in T cells, along with disease-specific downregulation of immune checkpoint molecules, including PD-1 and ICOS. Conclusions This study highlights the critical involvement of immune activation and mitochondrial dysfunction in the pathophysiology of MMD, providing novel insights into disease mechanisms and identifying immunometabolic pathways as potential targets for therapeutic intervention.https://doi.org/10.1186/s12974-025-03479-3Moyamoya diseaseT cellsMitochondrial dysfunctionImmunometabolismMass cytometry |
| spellingShingle | Chenglong Liu Junsheng Li Siqi Mou Yuheng Pang Liujia Chan Qiheng He Wei Liu Zhikang Zhao Bojian Zhang Zhiyao Zheng Wei Sun Xiangjun Shi Qian Zhang Rong Wang Yan Zhang Wenjing Wang Dong Zhang Peicong Ge Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders Journal of Neuroinflammation Moyamoya disease T cells Mitochondrial dysfunction Immunometabolism Mass cytometry |
| title | Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders |
| title_full | Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders |
| title_fullStr | Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders |
| title_full_unstemmed | Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders |
| title_short | Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders |
| title_sort | circulating t cell atlas in moyamoya disease insights into immunopathogenesis of cerebrovascular disorders |
| topic | Moyamoya disease T cells Mitochondrial dysfunction Immunometabolism Mass cytometry |
| url | https://doi.org/10.1186/s12974-025-03479-3 |
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