Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination

Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination

Abstract The DNA damage response plays a pivotal role in ovarian aging. Breast cancer susceptibility gene 2 (BRCA2), which participates in homologous recombination (HR), is a key regulator of natural menopause. Rare BRCA2 variants have been identified in patients with premature ovarian insufficiency...

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Bibliographic Details
Main Authors: Xinyi Wu, Qian Zhang, Chang Li, Shuning Zhuang, Hongyuan Liu, Xue Jiao, Shidou Zhao, Yingying Qin, Ting Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08426-9
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