Antagonizing IL-6 receptor restores pancreatic tissue resident NK cells activation and ameliorates pancreatic injury in the mouse model of MASH

Antagonizing IL-6 receptor restores pancreatic tissue resident NK cells activation and ameliorates pancreatic injury in the mouse model of MASH

Background and aimMetabolic-associated steatohepatitis (MASH) and pancreatic inflammation are key complications of obesity-related metabolic syndrome. Elevated IL-6; a proinflammatory cytokine, contributes to liver steatosis and pancreatic β-islet cells dysfunction. This study explores pancreatic ti...

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Bibliographic Details
Main Authors: Johnny Amer, Diana Abu Arra, Ahmad Salhab, Faris Kayed, Muneer Maali, Raghad Shweiki, Mustafa Ghanim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
pancreatic injury
pancreatic fibrosis
trNK cells
IL-6
IL-6R
MASH
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1611637/full
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