Marginal adaptation and porosity of calcium silicate-based cements in furcation perforations: a micro-CT comparative study
Abstract This ex-vivo study compares the adaptation, porosity, and sealing performance of ProRoot MTA, NeoPutty, and Biodentine in standardized, simulated furcation perforations created in extracted mandibular molars using clinical evaluation and high-resolution micro-computed tomography (micro-CT)....
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Nature Portfolio
2025-06-01
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| Online Access: | https://doi.org/10.1038/s41598-025-03729-7 |
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| author | María Rojo-Carpintero Ana Martín-Díaz Juan Miraglia Cantarini Natalia Navarrete Alejandro R. Pérez Giulia Malvicini José Aranguren David Rubio-Flores |
| author_facet | María Rojo-Carpintero Ana Martín-Díaz Juan Miraglia Cantarini Natalia Navarrete Alejandro R. Pérez Giulia Malvicini José Aranguren David Rubio-Flores |
| author_sort | María Rojo-Carpintero |
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| description | Abstract This ex-vivo study compares the adaptation, porosity, and sealing performance of ProRoot MTA, NeoPutty, and Biodentine in standardized, simulated furcation perforations created in extracted mandibular molars using clinical evaluation and high-resolution micro-computed tomography (micro-CT). Thirty-six mandibular molars with furcation perforations were randomly assigned to three groups (n = 12). Clinical evaluation assessed adaptation, porosity, and overfilling, while micro-computed tomography (micro-CT) provided quantitative data on voids and gaps. Statistical analysis used chi-square, Kruskal–Wallis, and Mann–Whitney U tests. NeoPutty and ProRoot MTA showed superior adaptation compared to Biodentine (p < 0.05). Biodentine showed higher porosity (28.44%) than ProRoot MTA (0%) and NeoPutty (8.3%) (p < 0.001). Biodentine also had the highest void volume (1.05 mm3) and gap volume (1.37 mm3), while ProRoot MTA recorded the lowest void volume (0.59 mm3), and NeoPutty had the smallest gap volume (0.85 mm3). No significant differences were observed in overfilling rates. Overall, ProRoot MTA exhibited the most consistent sealing ability, whereas NeoPutty emerged as a viable alternative due to its favorable handling and reliable adaptation. Biodentine, by contrast, showed the poorest performance in terms of structural integrity and sealing capacity. Within the limitations of this study, these findings support the use of ProRoot MTA or NeoPutty for furcation perforation repair, while suggesting more cautious use of Biodentine in such applications. |
| format | Article |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-cffebe26cca6433583ef275cfda0b9582025-08-20T02:30:46ZengNature PortfolioScientific Reports2045-23222025-06-0115111010.1038/s41598-025-03729-7Marginal adaptation and porosity of calcium silicate-based cements in furcation perforations: a micro-CT comparative studyMaría Rojo-Carpintero0Ana Martín-Díaz1Juan Miraglia Cantarini2Natalia Navarrete3Alejandro R. Pérez4Giulia Malvicini5José Aranguren6David Rubio-Flores7Department of Endodontics, Rey Juan Carlos UniversityDepartment of Endodontics, Rey Juan Carlos UniversityPrivate Practice in Microscopic Endodontics and Apical MicrosurgeryDepartment of Endodontics, Rey Juan Carlos UniversityDepartment of Endodontics, Rey Juan Carlos UniversityDepartment of Medical Biotechnologies, Unit of Endodontics and Restorative Dentistry, University of SienaDepartment of Endodontics, Rey Juan Carlos UniversityDepartment of Endodontics, Rey Juan Carlos UniversityAbstract This ex-vivo study compares the adaptation, porosity, and sealing performance of ProRoot MTA, NeoPutty, and Biodentine in standardized, simulated furcation perforations created in extracted mandibular molars using clinical evaluation and high-resolution micro-computed tomography (micro-CT). Thirty-six mandibular molars with furcation perforations were randomly assigned to three groups (n = 12). Clinical evaluation assessed adaptation, porosity, and overfilling, while micro-computed tomography (micro-CT) provided quantitative data on voids and gaps. Statistical analysis used chi-square, Kruskal–Wallis, and Mann–Whitney U tests. NeoPutty and ProRoot MTA showed superior adaptation compared to Biodentine (p < 0.05). Biodentine showed higher porosity (28.44%) than ProRoot MTA (0%) and NeoPutty (8.3%) (p < 0.001). Biodentine also had the highest void volume (1.05 mm3) and gap volume (1.37 mm3), while ProRoot MTA recorded the lowest void volume (0.59 mm3), and NeoPutty had the smallest gap volume (0.85 mm3). No significant differences were observed in overfilling rates. Overall, ProRoot MTA exhibited the most consistent sealing ability, whereas NeoPutty emerged as a viable alternative due to its favorable handling and reliable adaptation. Biodentine, by contrast, showed the poorest performance in terms of structural integrity and sealing capacity. Within the limitations of this study, these findings support the use of ProRoot MTA or NeoPutty for furcation perforation repair, while suggesting more cautious use of Biodentine in such applications.https://doi.org/10.1038/s41598-025-03729-7Calcium silicate-based cementFurcal perforationsMandibular molarsMarginal adaptationMicro-computed tomographyPerforation sealing |
| spellingShingle | María Rojo-Carpintero Ana Martín-Díaz Juan Miraglia Cantarini Natalia Navarrete Alejandro R. Pérez Giulia Malvicini José Aranguren David Rubio-Flores Marginal adaptation and porosity of calcium silicate-based cements in furcation perforations: a micro-CT comparative study Scientific Reports Calcium silicate-based cement Furcal perforations Mandibular molars Marginal adaptation Micro-computed tomography Perforation sealing |
| title | Marginal adaptation and porosity of calcium silicate-based cements in furcation perforations: a micro-CT comparative study |
| title_full | Marginal adaptation and porosity of calcium silicate-based cements in furcation perforations: a micro-CT comparative study |
| title_fullStr | Marginal adaptation and porosity of calcium silicate-based cements in furcation perforations: a micro-CT comparative study |
| title_full_unstemmed | Marginal adaptation and porosity of calcium silicate-based cements in furcation perforations: a micro-CT comparative study |
| title_short | Marginal adaptation and porosity of calcium silicate-based cements in furcation perforations: a micro-CT comparative study |
| title_sort | marginal adaptation and porosity of calcium silicate based cements in furcation perforations a micro ct comparative study |
| topic | Calcium silicate-based cement Furcal perforations Mandibular molars Marginal adaptation Micro-computed tomography Perforation sealing |
| url | https://doi.org/10.1038/s41598-025-03729-7 |
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