Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study
Abstract Background New daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. Specific abnormalities in gray matter and white matter structure are associated with pain, but have not been well studied in NDPH. The objective...
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BMC
2024-11-01
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| Series: | The Journal of Headache and Pain |
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| Online Access: | https://doi.org/10.1186/s10194-024-01899-9 |
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| author | Di Zhang Fangrong Zong Yanliang Mei Kun Zhao Dong Qiu Zhonghua Xiong Xiaoshuang Li Hefei Tang Peng Zhang Mantian Zhang Yaqing Zhang Xueying Yu Zhe Wang Yong Liu Binbin Sui Yonggang Wang |
| author_facet | Di Zhang Fangrong Zong Yanliang Mei Kun Zhao Dong Qiu Zhonghua Xiong Xiaoshuang Li Hefei Tang Peng Zhang Mantian Zhang Yaqing Zhang Xueying Yu Zhe Wang Yong Liu Binbin Sui Yonggang Wang |
| author_sort | Di Zhang |
| collection | DOAJ |
| description | Abstract Background New daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. Specific abnormalities in gray matter and white matter structure are associated with pain, but have not been well studied in NDPH. The objective of this work is to explore the fiber tracts and structural connectivity, which can help reveal unique gray and white matter structural abnormalities in NDPH. Methods The regional radiomics similarity networks were calculated from T1 weighted (T1w) MRI to depict the gray matter structure. The fiber connectivity matrices weighted by diffusion metrics like fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) were built, meanwhile the fiber tracts were segmented by anatomically-guided superficial fiber segmentation (Anat-SFSeg) method to explore the white matter structure from diffusion MRI. The considerable different neuroimaging features between NDPH and healthy controls (HC) were extracted from the connectivity and tract-based analyses. Finally, decision tree regression was used to predict the clinical scores (i.e. pain intensity) from the above neuroimaging features. Results T1w and diffusion MRI data were available in 51 participants after quality control: 22 patients with NDPH and 29 HCs. Significantly decreased morphological similarity was found between the right superior frontal gyrus and right hippocampus. The superficial white matter (SWM) showed significantly decreased FA in fiber tracts including the right superficial-frontal, left superficial-occipital, bilateral superficial-occipital-temporal (Sup-OT) and right superficial-temporal, meanwhile significant increased RD was found in the left Sup-OT. For the fiber connectivity, NDPH showed significantly decreased FA in the bilateral basal ganglion and temporal lobe, increased MD in the right frontal lobe, and increased RD in the right frontal lobe and left temporal-occipital lobe. Clinical scores could be predicted dominantly by the above significantly different neuroimaging features through decision tree regression. Conclusions Our research indicates the structural abnormalities of SWM and the neural pathways projected between regions like right hippocampus and left caudate nucleus, along with morphological similarity changes between the right superior frontal gyrus and right hippocampus, constitute the pathological features of NDPH. The decision tree regression demonstrates correlations between these structural changes and clinical scores. |
| format | Article |
| id | doaj-art-cffe4e495ec94e2fbc3869727c3fc560 |
| institution | DOAJ |
| issn | 1129-2377 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj-art-cffe4e495ec94e2fbc3869727c3fc5602025-08-20T02:50:04ZengBMCThe Journal of Headache and Pain1129-23772024-11-0125111410.1186/s10194-024-01899-9Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific studyDi Zhang0Fangrong Zong1Yanliang Mei2Kun Zhao3Dong Qiu4Zhonghua Xiong5Xiaoshuang Li6Hefei Tang7Peng Zhang8Mantian Zhang9Yaqing Zhang10Xueying Yu11Zhe Wang12Yong Liu13Binbin Sui14Yonggang Wang15School of Artificial Intelligence, Beijing University of Posts and TelecommunicationsSchool of Artificial Intelligence, Beijing University of Posts and TelecommunicationsHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversitySchool of Artificial Intelligence, Beijing University of Posts and TelecommunicationsHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Dalian Medical UniversitySchool of Artificial Intelligence, Beijing University of Posts and TelecommunicationsTiantan Neuroimaging Center for Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical UniversityHeadache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background New daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. Specific abnormalities in gray matter and white matter structure are associated with pain, but have not been well studied in NDPH. The objective of this work is to explore the fiber tracts and structural connectivity, which can help reveal unique gray and white matter structural abnormalities in NDPH. Methods The regional radiomics similarity networks were calculated from T1 weighted (T1w) MRI to depict the gray matter structure. The fiber connectivity matrices weighted by diffusion metrics like fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) were built, meanwhile the fiber tracts were segmented by anatomically-guided superficial fiber segmentation (Anat-SFSeg) method to explore the white matter structure from diffusion MRI. The considerable different neuroimaging features between NDPH and healthy controls (HC) were extracted from the connectivity and tract-based analyses. Finally, decision tree regression was used to predict the clinical scores (i.e. pain intensity) from the above neuroimaging features. Results T1w and diffusion MRI data were available in 51 participants after quality control: 22 patients with NDPH and 29 HCs. Significantly decreased morphological similarity was found between the right superior frontal gyrus and right hippocampus. The superficial white matter (SWM) showed significantly decreased FA in fiber tracts including the right superficial-frontal, left superficial-occipital, bilateral superficial-occipital-temporal (Sup-OT) and right superficial-temporal, meanwhile significant increased RD was found in the left Sup-OT. For the fiber connectivity, NDPH showed significantly decreased FA in the bilateral basal ganglion and temporal lobe, increased MD in the right frontal lobe, and increased RD in the right frontal lobe and left temporal-occipital lobe. Clinical scores could be predicted dominantly by the above significantly different neuroimaging features through decision tree regression. Conclusions Our research indicates the structural abnormalities of SWM and the neural pathways projected between regions like right hippocampus and left caudate nucleus, along with morphological similarity changes between the right superior frontal gyrus and right hippocampus, constitute the pathological features of NDPH. The decision tree regression demonstrates correlations between these structural changes and clinical scores.https://doi.org/10.1186/s10194-024-01899-9New daily persistent headacheWhite matterStructural connectivityDiffusion MRIDiffusion tensor imaging |
| spellingShingle | Di Zhang Fangrong Zong Yanliang Mei Kun Zhao Dong Qiu Zhonghua Xiong Xiaoshuang Li Hefei Tang Peng Zhang Mantian Zhang Yaqing Zhang Xueying Yu Zhe Wang Yong Liu Binbin Sui Yonggang Wang Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study The Journal of Headache and Pain New daily persistent headache White matter Structural connectivity Diffusion MRI Diffusion tensor imaging |
| title | Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study |
| title_full | Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study |
| title_fullStr | Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study |
| title_full_unstemmed | Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study |
| title_short | Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study |
| title_sort | morphological similarity and white matter structural mapping of new daily persistent headache a structural connectivity and tract specific study |
| topic | New daily persistent headache White matter Structural connectivity Diffusion MRI Diffusion tensor imaging |
| url | https://doi.org/10.1186/s10194-024-01899-9 |
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