The novel highly effective ir-photosensitizer for photodynamic therapy of cancer
The present article is devoted to the synthesis and investigation of biological and physico-chemical properties of the bacteriopurpurinimide derivative that was used as a photosensitizer. These substances have an ability to accumulate selectively in the malignant tumours. Also this class of photosen...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2014-06-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/461 |
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| author | I. V. Pantyushenko M. A. Grin R. I. Yakubovskaya E. A. Plotnikova N. B. Morozova A. A. Tsygankov A. F. Mironov |
| author_facet | I. V. Pantyushenko M. A. Grin R. I. Yakubovskaya E. A. Plotnikova N. B. Morozova A. A. Tsygankov A. F. Mironov |
| author_sort | I. V. Pantyushenko |
| collection | DOAJ |
| description | The present article is devoted to the synthesis and investigation of biological and physico-chemical properties of the bacteriopurpurinimide derivative that was used as a photosensitizer. These substances have an ability to accumulate selectively in the malignant tumours. Also this class of photosensitizers is of particular interest because of their strong light absorbtion spectrum in red and NIR-region in the “window of tissue transparency”. This property affords to treat deep-seated tumours at the depth of 2 cm. In this study it was implemented the method of photodynamic therapy of cancer. The photosensitizer for this study was prepared as the nanostructured water-soluble micellar dispersion of O-propyloxime-N-propoxybacteriopurpurinimide methyl ester. The photodynamic therapy using this substance provided the highly effective photoinduced antitumour in vitro and in vivo activity, 100% regression of the tumour and 90% cure of animals. |
| format | Article |
| id | doaj-art-cffe07b1c55949d4a9403379f9d3ad82 |
| institution | DOAJ |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2014-06-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-cffe07b1c55949d4a9403379f9d3ad822025-08-20T03:23:08ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752014-06-0193310455The novel highly effective ir-photosensitizer for photodynamic therapy of cancerI. V. Pantyushenko0M. A. Grin1R. I. Yakubovskaya2E. A. Plotnikova3N. B. Morozova4A. A. Tsygankov5A. F. Mironov6M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571P.A. Hertzen Moscow Institute of Oncology, Moscow, 125284P.A. Hertzen Moscow Institute of Oncology, Moscow, 125284P.A. Hertzen Moscow Institute of Oncology, Moscow, 125284Institute of Basic Biological Problems RAS, Pushchino, Moscow Region, 142290M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571The present article is devoted to the synthesis and investigation of biological and physico-chemical properties of the bacteriopurpurinimide derivative that was used as a photosensitizer. These substances have an ability to accumulate selectively in the malignant tumours. Also this class of photosensitizers is of particular interest because of their strong light absorbtion spectrum in red and NIR-region in the “window of tissue transparency”. This property affords to treat deep-seated tumours at the depth of 2 cm. In this study it was implemented the method of photodynamic therapy of cancer. The photosensitizer for this study was prepared as the nanostructured water-soluble micellar dispersion of O-propyloxime-N-propoxybacteriopurpurinimide methyl ester. The photodynamic therapy using this substance provided the highly effective photoinduced antitumour in vitro and in vivo activity, 100% regression of the tumour and 90% cure of animals.https://www.finechem-mirea.ru/jour/article/view/461bacteriochlorophyll a, bacteriopurpurin, bacteriopurpurinimide, photosensitizer, photodynamic therapy, malignant tumours. |
| spellingShingle | I. V. Pantyushenko M. A. Grin R. I. Yakubovskaya E. A. Plotnikova N. B. Morozova A. A. Tsygankov A. F. Mironov The novel highly effective ir-photosensitizer for photodynamic therapy of cancer Тонкие химические технологии bacteriochlorophyll a, bacteriopurpurin, bacteriopurpurinimide, photosensitizer, photodynamic therapy, malignant tumours. |
| title | The novel highly effective ir-photosensitizer for photodynamic therapy of cancer |
| title_full | The novel highly effective ir-photosensitizer for photodynamic therapy of cancer |
| title_fullStr | The novel highly effective ir-photosensitizer for photodynamic therapy of cancer |
| title_full_unstemmed | The novel highly effective ir-photosensitizer for photodynamic therapy of cancer |
| title_short | The novel highly effective ir-photosensitizer for photodynamic therapy of cancer |
| title_sort | novel highly effective ir photosensitizer for photodynamic therapy of cancer |
| topic | bacteriochlorophyll a, bacteriopurpurin, bacteriopurpurinimide, photosensitizer, photodynamic therapy, malignant tumours. |
| url | https://www.finechem-mirea.ru/jour/article/view/461 |
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