Examination of the functions and mechanism of KCP in mediating paclitaxel resistance in cervical squamous carcinoma cells

Examination of the functions and mechanism of KCP in mediating paclitaxel resistance in cervical squamous carcinoma cells

ObjectiveTo evaluate the mechanism of Kielin/chordin-like protein (KCP) in the resistance of cervical cancer cells to paclitaxel.MethodA cervical squamous carcinoma cell line (SiHa) with KCP knockout was constructed and treated with paclitaxel. Key cell functions were assessed by colony formation as...

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Bibliographic Details
Main Authors: Yue He, Jian-Qing Xu, Jing-Jing Zhang, Zhen-You Liu, Chen Ji, Yang Liu, Yun-Fan Wang, Ming Wang, Yu-Mei Wu, Yan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
Kielin/chordin-like protein
paclitaxel resistance
cervical squamous cell carcinoma
mechanism
functions
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1550032/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1550032/full

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