Molecular pharmacokinetic mechanism of quercetin-encapsulated polymeric micelles in alleviating cisplatin-induced nephrotoxicity and enhancing antineoplastic effects

Molecular pharmacokinetic mechanism of quercetin-encapsulated polymeric micelles in alleviating cisplatin-induced nephrotoxicity and enhancing antineoplastic effects

IntroductionCisplatin (DDP), a platinum-based chemotherapy drug, shows broad antineoplastic activity, however, its clinical use is limited by dose-dependent nephrotoxicity, a major challenge in cancer therapy. The purpose of this study was to investigate the mechanism by which quercetin-polyethylene...

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Bibliographic Details
Main Authors: Tangna Hao, Xiaokui Huo, Zhen Li, Changyuan Wang, Sha Wu, Anni Song, Fengyu Zhang, Kexin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
cisplatin
nephrotoxicity
quercetin
polymeric micelles
antitumor potency
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1590688/full
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