RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons

RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons

Abstract Background RNA helicase MOV10 is highly expressed in postnatal brain and associates with FMRP and AGO2, suggesting a role in translation regulation in learning and memory. Results We generated a brain-specific knockout mouse (Mov10 Deletion) with greatly reduced MOV10 expression in cortex a...

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Bibliographic Details
Main Authors: Temirlan Shilikbay, Aatiqa Nawaz, Megan Doon, Stephanie Ceman
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Biology
Subjects:
MOV10
RNA helicase
AGO2
Hippocampal neurons
Cytoskeleton
NUMA1
Online Access:https://doi.org/10.1186/s12915-025-02138-6
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