BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study
Abstract Background Branched-chain amino acid (BCAA) has been reported to be associated with obesity, the association of BCAA with visceral fat area (VFA) and subcutaneous fat area (SFA) remained unclear in patients with type 2 diabetes. Methods This cross-sectional study was conducted in 284 patien...
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BMC
2024-11-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01768-1 |
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| author | Xinghua Cai Wenmin Li Liang Wang Yingying Shi Jie Gao Hongping Wang Tao Lei Jun Lu |
| author_facet | Xinghua Cai Wenmin Li Liang Wang Yingying Shi Jie Gao Hongping Wang Tao Lei Jun Lu |
| author_sort | Xinghua Cai |
| collection | DOAJ |
| description | Abstract Background Branched-chain amino acid (BCAA) has been reported to be associated with obesity, the association of BCAA with visceral fat area (VFA) and subcutaneous fat area (SFA) remained unclear in patients with type 2 diabetes. Methods This cross-sectional study was conducted in 284 patients with type 2 diabetes mellitus. Enzyme-linked immunospecific assay was used to measure levels of serum BCAA and branched-chain keto acid (BCKA). VFA and SFA were measured with bio-impedance analysis method. The association between BCAA and VFA was calculated using Pearson correlation and multivariable linear regression analysis. Results There were significant differences in the means of body mass index, waist circumstance, SFA and VFA among the three groups divided by total BCAA tertiles (all p < 0.05). Compared to patients with lower levels of serum BCAA (the lower tertile group), the means of VFA and SFA were significantly larger in the middle and upper tertile groups (all p < 0.05). However, the differences in above obesity parameters were nonsignificant according to various BCKA tertiles. Pearson correlation analysis also demonstrated that BCAA levels were positive associated with each obesity parameter (p < 0.05). Nevertheless, multivariable linear regression analysis showed that levels of serum BCAA were correlated with VFA, BMI and WC (all p < 0.05) rather than SFA after adjusted for other confounders. Conclusions levels of serum BCAA were more closely correlated with VFA than SFA, prospective studies should be warranted to further explore the mechanism mediating BCAA and visceral fat accumulation in Human beings. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-cff6736df3c047719fc2aacdcfbe34c8 |
| institution | OA Journals |
| issn | 1472-6823 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-cff6736df3c047719fc2aacdcfbe34c82025-08-20T02:13:26ZengBMCBMC Endocrine Disorders1472-68232024-11-012411710.1186/s12902-024-01768-1BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional studyXinghua Cai0Wenmin Li1Liang Wang2Yingying Shi3Jie Gao4Hongping Wang5Tao Lei6Jun Lu7Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Public Health, College of Health Professions, Marshall UniversityDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineAbstract Background Branched-chain amino acid (BCAA) has been reported to be associated with obesity, the association of BCAA with visceral fat area (VFA) and subcutaneous fat area (SFA) remained unclear in patients with type 2 diabetes. Methods This cross-sectional study was conducted in 284 patients with type 2 diabetes mellitus. Enzyme-linked immunospecific assay was used to measure levels of serum BCAA and branched-chain keto acid (BCKA). VFA and SFA were measured with bio-impedance analysis method. The association between BCAA and VFA was calculated using Pearson correlation and multivariable linear regression analysis. Results There were significant differences in the means of body mass index, waist circumstance, SFA and VFA among the three groups divided by total BCAA tertiles (all p < 0.05). Compared to patients with lower levels of serum BCAA (the lower tertile group), the means of VFA and SFA were significantly larger in the middle and upper tertile groups (all p < 0.05). However, the differences in above obesity parameters were nonsignificant according to various BCKA tertiles. Pearson correlation analysis also demonstrated that BCAA levels were positive associated with each obesity parameter (p < 0.05). Nevertheless, multivariable linear regression analysis showed that levels of serum BCAA were correlated with VFA, BMI and WC (all p < 0.05) rather than SFA after adjusted for other confounders. Conclusions levels of serum BCAA were more closely correlated with VFA than SFA, prospective studies should be warranted to further explore the mechanism mediating BCAA and visceral fat accumulation in Human beings. Clinical trial number Not applicable.https://doi.org/10.1186/s12902-024-01768-1Branched-chain amino acidsVisceral fat areaSubcutaneous fat areaObesityType 2 diabetes |
| spellingShingle | Xinghua Cai Wenmin Li Liang Wang Yingying Shi Jie Gao Hongping Wang Tao Lei Jun Lu BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study BMC Endocrine Disorders Branched-chain amino acids Visceral fat area Subcutaneous fat area Obesity Type 2 diabetes |
| title | BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study |
| title_full | BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study |
| title_fullStr | BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study |
| title_full_unstemmed | BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study |
| title_short | BCAA was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus: a cross-sectional study |
| title_sort | bcaa was more closely associated with visceral fat area than subcutaneous fat area in patients of type 2 diabetes mellitus a cross sectional study |
| topic | Branched-chain amino acids Visceral fat area Subcutaneous fat area Obesity Type 2 diabetes |
| url | https://doi.org/10.1186/s12902-024-01768-1 |
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