Diagnostic value of serum levels of interleukin-9,interleukin-18 and interleukin-32 in patients with multiple myeloma
Objective To explore the serum expressions of interleukin-9（IL-9）,interleukin-18（IL-18）and interleukin-32（IL-32）in patients with multiple myeloma（MM）and examine their values in predicting renal injury.Methods Seventy-eight MM patients from January 2015 to December 2019 were divided into phase I（n=15...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57904530&Fpath=home&index=0 |
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| Summary: | Objective To explore the serum expressions of interleukin-9（IL-9）,interleukin-18（IL-18）and interleukin-32（IL-32）in patients with multiple myeloma（MM）and examine their values in predicting renal injury.Methods Seventy-eight MM patients from January 2015 to December 2019 were divided into phase I（n=15）,phase II（n=26）and phase III（n=37）according to the International Staging System.Based upon renal function, they were divided into renal injury group（n=28）and renal non-injury group（n=50）.Another 50 normal subjects in the same period were selected as control group.The serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-microglobulin（β<sub>2</sub>-MG）were detected in each group.Receiver operating characteristic（ROC）curve was utilized for examining the values of serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG in the diagnosis of renal injury.Pearson’s correlation analysis was utilized for examining the correlation between serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG.Results The serum levels of IL-9[（63.15±18.36）ng/L vs（22.78±7.15）ng/L],IL-18[（580.64±70.35）ng/L vs（174.30±26.82）ng/L],IL-32[（817.62±112.36）ng/L vs（260.85±34.70）ng/L]and β<sub>2</sub>-MG]（6.50±2.52）mg/L vs（1.66±0.58）mg/L]were significantly higher in MM group than those in control group（P<0.001）.With the advancing of ISS stage, the serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG spiked in MM patients（P<0.001）.The serum levels of IL-9[（91.26±19.42）ng/L vs（45.30±14.20）ng/L],IL-18[（812.46±95.2）ng/L vs（407.28±53.60）ng/L],IL-32[（1130.85±154.70）ng/L vs（604.20±71.38） ng/L]and β<sub>2</sub>-MG[（10.18±4.75）mg/L vs（3.15±1.06） mg/L]were significantly higher in renal injury group than those in renal non-injury group（P<0.001）.ROC curve analysis revealed that the area under the curve（0.963,95%CI:0.905-0.997）of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG combined diagnosis of renal injury in MM was the largest and its sensitivity and specificity were 98.6% and 81.2%.Correlation analysis showed that serum levels of IL-9,IL-18,IL-32 and β<sub>2</sub>-MG were positively correlated in MM patients（P<0.001）.Conclusion The serum levels of IL-9,IL-18 and IL-32 are significantly elevated in MM patients.Correlated with disease stage and renal injury, combine detection of β<sub>2</sub>-MG has an excellent value in the diagnosis of renal injury in MM patients. |
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| ISSN: | 1671-2390 |