The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network?
Background: The mechanisms underlying extrapyramidal disorders and their anatomical substrate have been extensively investigated. Recently, the role of the claustrum in Parkinson’s disease and other neurodegenerative conditions has been better detailed. The main aim of this review was to summarize t...
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MDPI AG
2025-01-01
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| author | Marialuisa Zedde Rocco Quatrale Gianni Cossu Massimo Del Sette Rosario Pascarella |
| author_facet | Marialuisa Zedde Rocco Quatrale Gianni Cossu Massimo Del Sette Rosario Pascarella |
| author_sort | Marialuisa Zedde |
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| description | Background: The mechanisms underlying extrapyramidal disorders and their anatomical substrate have been extensively investigated. Recently, the role of the claustrum in Parkinson’s disease and other neurodegenerative conditions has been better detailed. The main aim of this review was to summarize the supporting evidence for the role of the claustrum in degenerative and vascular parkinsonism. Methods: The anatomy, biology, vascular supply, and connections of the claustrum in humans were identified and described, providing the substrate for the vascular involvement of the claustrum in large- and small-vessel disease. The vascular supply of the claustrum includes up to three different sources from a single artery, the middle cerebral artery, and it is known as territory with an intermediate hemodynamic risk. The connections of the claustrum make it a sensory integrator and a relevant point in several networks, from consciousness to movement planning. Conclusions: The claustrum is still an incompletely explained structure. However, recent description of its multiple connections indicate that it is involved in several diseases, including Parkinson’s disease. The evidence underlying its potential role in vascular parkinsonism is still scarce, but it might be a field warranting future investigations. |
| format | Article |
| id | doaj-art-cfec47f11b53470b8913f0b097b06a70 |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-cfec47f11b53470b8913f0b097b06a702025-08-20T02:01:21ZengMDPI AGLife2075-17292025-01-0115218010.3390/life15020180The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network?Marialuisa Zedde0Rocco Quatrale1Gianni Cossu2Massimo Del Sette3Rosario Pascarella4Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, ItalyDipartimento di Scienze Neurologiche, UOC di Neurologia—Ospedale dell’AngeloAULSS 3 Serenissima, 30174 Venice Mestre, ItalyNeurology Unit, Dept of Neuroscience, ARNAS Brotzu, 09047 Cagliari, ItalyNeurology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyNeuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, ItalyBackground: The mechanisms underlying extrapyramidal disorders and their anatomical substrate have been extensively investigated. Recently, the role of the claustrum in Parkinson’s disease and other neurodegenerative conditions has been better detailed. The main aim of this review was to summarize the supporting evidence for the role of the claustrum in degenerative and vascular parkinsonism. Methods: The anatomy, biology, vascular supply, and connections of the claustrum in humans were identified and described, providing the substrate for the vascular involvement of the claustrum in large- and small-vessel disease. The vascular supply of the claustrum includes up to three different sources from a single artery, the middle cerebral artery, and it is known as territory with an intermediate hemodynamic risk. The connections of the claustrum make it a sensory integrator and a relevant point in several networks, from consciousness to movement planning. Conclusions: The claustrum is still an incompletely explained structure. However, recent description of its multiple connections indicate that it is involved in several diseases, including Parkinson’s disease. The evidence underlying its potential role in vascular parkinsonism is still scarce, but it might be a field warranting future investigations.https://www.mdpi.com/2075-1729/15/2/180claustrummiddle cerebral arteryParkinson’s diseaseneurodegenerativevascular parkinsonismstroke |
| spellingShingle | Marialuisa Zedde Rocco Quatrale Gianni Cossu Massimo Del Sette Rosario Pascarella The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network? Life claustrum middle cerebral artery Parkinson’s disease neurodegenerative vascular parkinsonism stroke |
| title | The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network? |
| title_full | The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network? |
| title_fullStr | The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network? |
| title_full_unstemmed | The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network? |
| title_short | The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network? |
| title_sort | role of the claustrum in parkinson s disease and vascular parkinsonism a matter of network |
| topic | claustrum middle cerebral artery Parkinson’s disease neurodegenerative vascular parkinsonism stroke |
| url | https://www.mdpi.com/2075-1729/15/2/180 |
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