Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis
BackgroundEsophagectomy is the primary treatment for localized esophageal squamous cell carcinoma (ESCC). Intraoperative thoracic duct ligation (TDL) has been suggested as an adjunct to reduce the risk of postoperative chylothorax in patients with ESCC, but its effect on long-term oncologic outcomes...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1533378/full |
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| author | Ke-xun Li Ke-xun Li Si-miao Lu Si-miao Lu Chang-ding Li Chang-ding Li Cheng-hao Wang Jia-hua Lv Jia-hua Lv Qi-feng Wang Qi-feng Wang Yun-chao Huang Yong-tao Han Xue-feng Leng Lin Peng |
| author_facet | Ke-xun Li Ke-xun Li Si-miao Lu Si-miao Lu Chang-ding Li Chang-ding Li Cheng-hao Wang Jia-hua Lv Jia-hua Lv Qi-feng Wang Qi-feng Wang Yun-chao Huang Yong-tao Han Xue-feng Leng Lin Peng |
| author_sort | Ke-xun Li |
| collection | DOAJ |
| description | BackgroundEsophagectomy is the primary treatment for localized esophageal squamous cell carcinoma (ESCC). Intraoperative thoracic duct ligation (TDL) has been suggested as an adjunct to reduce the risk of postoperative chylothorax in patients with ESCC, but its effect on long-term oncologic outcomes remains uncertain.MethodsData from the Sichuan Cancer Hospital and Institute Esophageal Cancer Case Management Database were analyzed for patients treated between 2010 and 2017. Participants were classified into TDL and non-TDL groups. Univariate Cox regression analyses and propensity score matching (PSM) were used to identify independent risk factors for overall survival (OS).ResultsA total of 2,510 patients were included, with 2,095 in the TDL group and 415 in the non-TDL group. The median follow-up was 63.97 months. No significant differences in OS were observed between the TDL and non-TDL groups (HR: 1.13; 95% CI: 0.96–1.31; P = 0.13). After PSM, the analysis continued to show no significant differences between the groups (P = 0.72).ConclusionIntraoperative TDL during esophagectomy did not significantly impact long-term OS in patients with ESCC. |
| format | Article |
| id | doaj-art-cfebab9e3bd74f908e32c820cca5baf6 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-cfebab9e3bd74f908e32c820cca5baf62025-08-20T02:02:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15333781533378Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysisKe-xun Li0Ke-xun Li1Si-miao Lu2Si-miao Lu3Chang-ding Li4Chang-ding Li5Cheng-hao Wang6Jia-hua Lv7Jia-hua Lv8Qi-feng Wang9Qi-feng Wang10Yun-chao Huang11Yong-tao Han12Xue-feng Leng13Lin Peng14Department of Thoracic Surgery, Sichuan Clinical Research Centre for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Centre, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, Sichuan, ChinaDepartment of Thoracic and Cardiovascular Surgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital), Kunming, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Centre for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Centre, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, Sichuan, ChinaSchool of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Centre for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Centre, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, Sichuan, ChinaDepartment of Thoracic Surgery, Zigong First People's Hospital, Zigong, Sichuan, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Centre for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Centre, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, Sichuan, ChinaDepartment of Radiation Oncology, Sichuan Cancer Hospital & Institute, University of Electronic Science and Technology of China (UESTC), Chengdu, ChinaRadiation Oncology Key Laboratory of Sichuan Province, Chengdu, ChinaDepartment of Radiation Oncology, Sichuan Cancer Hospital & Institute, University of Electronic Science and Technology of China (UESTC), Chengdu, ChinaRadiation Oncology Key Laboratory of Sichuan Province, Chengdu, ChinaDepartment of Thoracic and Cardiovascular Surgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital), Kunming, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Centre for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Centre, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, Sichuan, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Centre for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Centre, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, Sichuan, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Centre for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Centre, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, Sichuan, ChinaBackgroundEsophagectomy is the primary treatment for localized esophageal squamous cell carcinoma (ESCC). Intraoperative thoracic duct ligation (TDL) has been suggested as an adjunct to reduce the risk of postoperative chylothorax in patients with ESCC, but its effect on long-term oncologic outcomes remains uncertain.MethodsData from the Sichuan Cancer Hospital and Institute Esophageal Cancer Case Management Database were analyzed for patients treated between 2010 and 2017. Participants were classified into TDL and non-TDL groups. Univariate Cox regression analyses and propensity score matching (PSM) were used to identify independent risk factors for overall survival (OS).ResultsA total of 2,510 patients were included, with 2,095 in the TDL group and 415 in the non-TDL group. The median follow-up was 63.97 months. No significant differences in OS were observed between the TDL and non-TDL groups (HR: 1.13; 95% CI: 0.96–1.31; P = 0.13). After PSM, the analysis continued to show no significant differences between the groups (P = 0.72).ConclusionIntraoperative TDL during esophagectomy did not significantly impact long-term OS in patients with ESCC.https://www.frontiersin.org/articles/10.3389/fonc.2025.1533378/fullesophageal squamous cell carcinomaintraoperative thoracic duct ligationesophagectomyoverall survivalpropensity score matching |
| spellingShingle | Ke-xun Li Ke-xun Li Si-miao Lu Si-miao Lu Chang-ding Li Chang-ding Li Cheng-hao Wang Jia-hua Lv Jia-hua Lv Qi-feng Wang Qi-feng Wang Yun-chao Huang Yong-tao Han Xue-feng Leng Lin Peng Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis Frontiers in Oncology esophageal squamous cell carcinoma intraoperative thoracic duct ligation esophagectomy overall survival propensity score matching |
| title | Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis |
| title_full | Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis |
| title_fullStr | Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis |
| title_full_unstemmed | Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis |
| title_short | Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis |
| title_sort | long term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation a large scale propensity score matching analysis |
| topic | esophageal squamous cell carcinoma intraoperative thoracic duct ligation esophagectomy overall survival propensity score matching |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1533378/full |
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