miR-361-5p contributes to the pathogenesis of Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. This study investigated the roles of HOMER1, ATAD1, and miR-361 in AD pathogenesis using microarray (GSE106241, GSE157239; n = 60) and RT-PCR (n = 100; 50 AD patients, 50 controls from Northwest Iran) analyses. Decreased...
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| Format: | Article |
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-17112-z |
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| author | Abbas Jalaiei Jalal Gharesouran Shahram Arsang-Jang Mahnaz Talebi Maryam Rezazadeh Soudeh Ghafouri-Fard |
| author_facet | Abbas Jalaiei Jalal Gharesouran Shahram Arsang-Jang Mahnaz Talebi Maryam Rezazadeh Soudeh Ghafouri-Fard |
| author_sort | Abbas Jalaiei |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. This study investigated the roles of HOMER1, ATAD1, and miR-361 in AD pathogenesis using microarray (GSE106241, GSE157239; n = 60) and RT-PCR (n = 100; 50 AD patients, 50 controls from Northwest Iran) analyses. Decreased expression of HOMER1 and ATAD1, key regulators of glutamatergic synapses, and miR-361, a potential regulator of both, was observed in AD brain tissue (GSE106241, categorized into seven Braak stages), suggesting a link between their dysregulation, impaired synaptic function, and increased neuroinflammation. However, blood-based RT-PCR showed no significant difference in HOMER1 or ATAD1. miR-361 was significantly lower in AD patients (adjusted p < 0.043). These findings, limited by sample size and lacking a formal power analysis, require further investigation to validate their potential as peripheral biomarkers for AD. Future studies with larger sample sizes are warranted. |
| format | Article |
| id | doaj-art-cfeaf42d83bf4c82bb8bb5477b45d56e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-cfeaf42d83bf4c82bb8bb5477b45d56e2025-08-24T11:19:18ZengNature PortfolioScientific Reports2045-23222025-08-0115111110.1038/s41598-025-17112-zmiR-361-5p contributes to the pathogenesis of Alzheimer’s diseaseAbbas Jalaiei0Jalal Gharesouran1Shahram Arsang-Jang2Mahnaz Talebi3Maryam Rezazadeh4Soudeh Ghafouri-Fard5Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical SciencesDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical SciencesCancer Gene Therapy Research Center, Zanjan University of Medical SciencesNeurosciences Research Center (NSRC), Tabriz University of Medical SciencesDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesAbstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. This study investigated the roles of HOMER1, ATAD1, and miR-361 in AD pathogenesis using microarray (GSE106241, GSE157239; n = 60) and RT-PCR (n = 100; 50 AD patients, 50 controls from Northwest Iran) analyses. Decreased expression of HOMER1 and ATAD1, key regulators of glutamatergic synapses, and miR-361, a potential regulator of both, was observed in AD brain tissue (GSE106241, categorized into seven Braak stages), suggesting a link between their dysregulation, impaired synaptic function, and increased neuroinflammation. However, blood-based RT-PCR showed no significant difference in HOMER1 or ATAD1. miR-361 was significantly lower in AD patients (adjusted p < 0.043). These findings, limited by sample size and lacking a formal power analysis, require further investigation to validate their potential as peripheral biomarkers for AD. Future studies with larger sample sizes are warranted.https://doi.org/10.1038/s41598-025-17112-zAlzheimer’s diseaseHOMER1ATAD1MIR-361Glutamatergic synapses |
| spellingShingle | Abbas Jalaiei Jalal Gharesouran Shahram Arsang-Jang Mahnaz Talebi Maryam Rezazadeh Soudeh Ghafouri-Fard miR-361-5p contributes to the pathogenesis of Alzheimer’s disease Scientific Reports Alzheimer’s disease HOMER1 ATAD1 MIR-361 Glutamatergic synapses |
| title | miR-361-5p contributes to the pathogenesis of Alzheimer’s disease |
| title_full | miR-361-5p contributes to the pathogenesis of Alzheimer’s disease |
| title_fullStr | miR-361-5p contributes to the pathogenesis of Alzheimer’s disease |
| title_full_unstemmed | miR-361-5p contributes to the pathogenesis of Alzheimer’s disease |
| title_short | miR-361-5p contributes to the pathogenesis of Alzheimer’s disease |
| title_sort | mir 361 5p contributes to the pathogenesis of alzheimer s disease |
| topic | Alzheimer’s disease HOMER1 ATAD1 MIR-361 Glutamatergic synapses |
| url | https://doi.org/10.1038/s41598-025-17112-z |
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