The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy
Cellular photothermal and chemical kinetic therapy has recently been acknowledged as an effective cancer treatment method. Photothermal therapy (PTT) works by transforming light energy into heat through the photothermal effects triggered by near-infrared (NIR) laser exposure. The employment of nanom...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2025-06-01
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| Series: | Nano Biomedicine and Engineering |
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| Online Access: | https://www.sciopen.com/article/10.26599/NBE.2024.9290105 |
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| author | Lingle Zhang Xiaoqing Qian Yingying Yang Tingting Xiang Jinrong SiTu Hongzhang Yan Kai Yang |
| author_facet | Lingle Zhang Xiaoqing Qian Yingying Yang Tingting Xiang Jinrong SiTu Hongzhang Yan Kai Yang |
| author_sort | Lingle Zhang |
| collection | DOAJ |
| description | Cellular photothermal and chemical kinetic therapy has recently been acknowledged as an effective cancer treatment method. Photothermal therapy (PTT) works by transforming light energy into heat through the photothermal effects triggered by near-infrared (NIR) laser exposure. The employment of nanomaterials as carriers for PTT agents or as PTT agents themselves offers improved therapeutic outcomes with fewer side effects through enhanced photothermal conversion efficiency, accumulation of the PTT agents in the tumor tissue. In this work, we synthesized new MoS2/MnO2 nanomaterials modified with bovine serum protein to enhance the effectiveness of the Fenton-like reaction between MoS2 and MnO2 to produce •OH through photothermolysis excitation using a near-infrared (NIR) 808 nm laser. In vitro measurements further confirmed the exceptional ability of MoS2/MnO2–modified bovine hemoglobin (BSA) to destroy cancer cells. We believe that photothermal therapy can offer new insights into cancer therapy and greatly enhance the efficacy of chemotherapeutic tumor treatments. |
| format | Article |
| id | doaj-art-cfe89dbddcd8467096555c8be2846a70 |
| institution | DOAJ |
| issn | 2097-3837 2150-5578 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj-art-cfe89dbddcd8467096555c8be2846a702025-08-20T02:43:10ZengTsinghua University PressNano Biomedicine and Engineering2097-38372150-55782025-06-0117227728610.26599/NBE.2024.9290105The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic TherapyLingle Zhang0Xiaoqing Qian1Yingying Yang2Tingting Xiang3Jinrong SiTu4Hongzhang Yan5Kai Yang6College of Fisheries and Life Science of Shanghai Ocean University, Shanghai 201306, ChinaInstitute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instruments, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaCollege of Fisheries and Life Science of Shanghai Ocean University, Shanghai 201306, ChinaSchool of Clinical Laboratory Science, Guizhou Medical University, Guiyang 550004, ChinaCollege of Fisheries and Life Science of Shanghai Ocean University, Shanghai 201306, ChinaCollege of Fisheries and Life Science of Shanghai Ocean University, Shanghai 201306, ChinaCollege of Fisheries and Life Science of Shanghai Ocean University, Shanghai 201306, ChinaCellular photothermal and chemical kinetic therapy has recently been acknowledged as an effective cancer treatment method. Photothermal therapy (PTT) works by transforming light energy into heat through the photothermal effects triggered by near-infrared (NIR) laser exposure. The employment of nanomaterials as carriers for PTT agents or as PTT agents themselves offers improved therapeutic outcomes with fewer side effects through enhanced photothermal conversion efficiency, accumulation of the PTT agents in the tumor tissue. In this work, we synthesized new MoS2/MnO2 nanomaterials modified with bovine serum protein to enhance the effectiveness of the Fenton-like reaction between MoS2 and MnO2 to produce •OH through photothermolysis excitation using a near-infrared (NIR) 808 nm laser. In vitro measurements further confirmed the exceptional ability of MoS2/MnO2–modified bovine hemoglobin (BSA) to destroy cancer cells. We believe that photothermal therapy can offer new insights into cancer therapy and greatly enhance the efficacy of chemotherapeutic tumor treatments.https://www.sciopen.com/article/10.26599/NBE.2024.9290105nanomaterialsphotothermal therapychemical kineticssynergistic therapy |
| spellingShingle | Lingle Zhang Xiaoqing Qian Yingying Yang Tingting Xiang Jinrong SiTu Hongzhang Yan Kai Yang The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy Nano Biomedicine and Engineering nanomaterials photothermal therapy chemical kinetics synergistic therapy |
| title | The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy |
| title_full | The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy |
| title_fullStr | The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy |
| title_full_unstemmed | The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy |
| title_short | The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy |
| title_sort | novel mos2 mno2 bsa nanocomposite significantly enhances antitumour efficacy through synergistic photothermal therapy hemodynamic therapy |
| topic | nanomaterials photothermal therapy chemical kinetics synergistic therapy |
| url | https://www.sciopen.com/article/10.26599/NBE.2024.9290105 |
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