Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus
Background/Objectives: Diabetes mellitus (DM) is a complex and heterogenous disease classified as a group of metabolic disorders characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It leads to various complications, some of which are macrovasc...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/17/11/1538 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846152743183450112 |
|---|---|
| author | Juozas R. Lazutka Kristina Daniūnaitė Veronika Dedonytė Aistė Popandopula Karolina Žukaitė Žydrūnė Visockienė Laura Šiaulienė |
| author_facet | Juozas R. Lazutka Kristina Daniūnaitė Veronika Dedonytė Aistė Popandopula Karolina Žukaitė Žydrūnė Visockienė Laura Šiaulienė |
| author_sort | Juozas R. Lazutka |
| collection | DOAJ |
| description | Background/Objectives: Diabetes mellitus (DM) is a complex and heterogenous disease classified as a group of metabolic disorders characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It leads to various complications, some of which are macrovascular or microvascular complications, like diabetic polyneuropathy (DPN), having a profound impact on patients’ quality of life. Oxidative stress (OS) is one of the significant mechanisms in the development and progression of DPN. Thus, targeting OS pathways by antioxidants, such as α-lipoic acid (ALA), could represent a promising therapeutic strategy for alleviating neuropathic symptoms. The aim of our study was to evaluate whether short-term (from 4 to 9 days) intravenous administration of ALA could cause any measurable improvement in subjects with DM. Methods: Sixteen subjects with DM (six type 1 and ten type 2) and sixteen nondiabetic subjects matched by sex and age were recruited to this study. Only subjects with DM received treatment with ALA (600 mg daily). Pain intensity and biomarkers of DNA damage including plasma concentration of 8-hydroxy-2′-deoxyguanosine (8-OHdG), frequency of micronucleated lymphocytes (MN), and frequency of sister-chromatid exchanges (SCEs), were measured before and after the treatment with ALA. Results: Pain intensity and 8-OHdG levels were significantly lower in DM subjects after the ALA treatment than before the treatment. However, no changes in the frequency of SCEs and MN were observed. Conclusions: Our results show some evidence that even a short-term intravenous treatment with ALA could be beneficial for diabetic subjects, reducing pain intensity and concentration of 8-OHdG in blood plasma. |
| format | Article |
| id | doaj-art-cfe3a2c85ca74dea9e6e61ac3e202b05 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-cfe3a2c85ca74dea9e6e61ac3e202b052024-11-26T18:17:32ZengMDPI AGPharmaceuticals1424-82472024-11-011711153810.3390/ph17111538Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes MellitusJuozas R. Lazutka0Kristina Daniūnaitė1Veronika Dedonytė2Aistė Popandopula3Karolina Žukaitė4Žydrūnė Visockienė5Laura Šiaulienė6Life Sciences Center, Vilnius University, Saulėtekio Al. 7, LT-10257 Vilnius, LithuaniaLife Sciences Center, Vilnius University, Saulėtekio Al. 7, LT-10257 Vilnius, LithuaniaLife Sciences Center, Vilnius University, Saulėtekio Al. 7, LT-10257 Vilnius, LithuaniaLife Sciences Center, Vilnius University, Saulėtekio Al. 7, LT-10257 Vilnius, LithuaniaLife Sciences Center, Vilnius University, Saulėtekio Al. 7, LT-10257 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, M. K. Čiurlionio St. 21, LT-03101 Vilnius, LithuaniaLife Sciences Center, Vilnius University, Saulėtekio Al. 7, LT-10257 Vilnius, LithuaniaBackground/Objectives: Diabetes mellitus (DM) is a complex and heterogenous disease classified as a group of metabolic disorders characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It leads to various complications, some of which are macrovascular or microvascular complications, like diabetic polyneuropathy (DPN), having a profound impact on patients’ quality of life. Oxidative stress (OS) is one of the significant mechanisms in the development and progression of DPN. Thus, targeting OS pathways by antioxidants, such as α-lipoic acid (ALA), could represent a promising therapeutic strategy for alleviating neuropathic symptoms. The aim of our study was to evaluate whether short-term (from 4 to 9 days) intravenous administration of ALA could cause any measurable improvement in subjects with DM. Methods: Sixteen subjects with DM (six type 1 and ten type 2) and sixteen nondiabetic subjects matched by sex and age were recruited to this study. Only subjects with DM received treatment with ALA (600 mg daily). Pain intensity and biomarkers of DNA damage including plasma concentration of 8-hydroxy-2′-deoxyguanosine (8-OHdG), frequency of micronucleated lymphocytes (MN), and frequency of sister-chromatid exchanges (SCEs), were measured before and after the treatment with ALA. Results: Pain intensity and 8-OHdG levels were significantly lower in DM subjects after the ALA treatment than before the treatment. However, no changes in the frequency of SCEs and MN were observed. Conclusions: Our results show some evidence that even a short-term intravenous treatment with ALA could be beneficial for diabetic subjects, reducing pain intensity and concentration of 8-OHdG in blood plasma.https://www.mdpi.com/1424-8247/17/11/1538neuropathic painα-lipoic aciddiabetic polyneuropathyDNA damage |
| spellingShingle | Juozas R. Lazutka Kristina Daniūnaitė Veronika Dedonytė Aistė Popandopula Karolina Žukaitė Žydrūnė Visockienė Laura Šiaulienė Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus Pharmaceuticals neuropathic pain α-lipoic acid diabetic polyneuropathy DNA damage |
| title | Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus |
| title_full | Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus |
| title_fullStr | Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus |
| title_full_unstemmed | Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus |
| title_short | Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus |
| title_sort | effects of short term treatment with α lipoic acid on neuropathic pain and biomarkers of dna damage in patients with diabetes mellitus |
| topic | neuropathic pain α-lipoic acid diabetic polyneuropathy DNA damage |
| url | https://www.mdpi.com/1424-8247/17/11/1538 |
| work_keys_str_mv | AT juozasrlazutka effectsofshorttermtreatmentwithalipoicacidonneuropathicpainandbiomarkersofdnadamageinpatientswithdiabetesmellitus AT kristinadaniunaite effectsofshorttermtreatmentwithalipoicacidonneuropathicpainandbiomarkersofdnadamageinpatientswithdiabetesmellitus AT veronikadedonyte effectsofshorttermtreatmentwithalipoicacidonneuropathicpainandbiomarkersofdnadamageinpatientswithdiabetesmellitus AT aistepopandopula effectsofshorttermtreatmentwithalipoicacidonneuropathicpainandbiomarkersofdnadamageinpatientswithdiabetesmellitus AT karolinazukaite effectsofshorttermtreatmentwithalipoicacidonneuropathicpainandbiomarkersofdnadamageinpatientswithdiabetesmellitus AT zydrunevisockiene effectsofshorttermtreatmentwithalipoicacidonneuropathicpainandbiomarkersofdnadamageinpatientswithdiabetesmellitus AT laurasiauliene effectsofshorttermtreatmentwithalipoicacidonneuropathicpainandbiomarkersofdnadamageinpatientswithdiabetesmellitus |