CRF1 receptor antagonists in congenital adrenal hyperplasia: A systematic review and meta-analysis of phase 2 open-label and phase 3 clinical trials

CRF1 receptor antagonists in congenital adrenal hyperplasia: A systematic review and meta-analysis of phase 2 open-label and phase 3 clinical trials

Introduction: Classical Congenital Adrenal Hyperplasia (CAH) due to 21 hydroxylase deficiency is a rare autosomal recessive disorder. Recent clinical trials indicate that type 1 Corticotropin-releasing hormone receptor OR CRFR1 receptor OR CRF1 antagonists could provide a new treatment option for CA...

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Main Authors: Mir wajid Majeed, Emma Finnegan, Mariano Gallo Ruelas, Marco Quirós, Marina Barbosa da Silva, Issa Salha, Catalina Herrán-Fonseca, Helen Michaela de Oliveira, Melissa Chacón Quirós, Raheel Ahmed, Zainab Humayun, Tajamul Hussain Shah, Mohammad Ashraf Ganie
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Endocrine and Metabolic Science
Subjects:
CAH
CRF-1 receptor antagonists
ACTH
Online Access:http://www.sciencedirect.com/science/article/pii/S2666396125000330
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